Prostate Cancer Risk among Men with Diabetes Mellitus (Spain)

Objective: Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK. Methods: Population based case-control study nested in a cohort. Results: We identified 2,183 incident...

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Bibliographic Details
Published in:Cancer causes & control 2005-11, Vol.16 (9), p.1055-1058
Main Authors: González-Pérez, A., Rodríguez, L. A. García
Format: Article
Language:English
Subjects:
Aged
Antidiabetics
Cancer therapies
Case-Control Studies
Cell division
Databases as Topic
Diabetes
Diabetes complications
Diabetes mellitus
Diabetes Mellitus - drug therapy
Family Practice
General practice
Humans
Hypoglycemic agents
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Incidence
Insulin
Insulin-like growth factors
Male
Medical referrals
Patient admissions
Practice research
Prostate cancer
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - prevention & control
Risk
Risk Assessment
Risk Factors
Type 1 diabetes mellitus
Type 2 diabetes mellitus
United Kingdom - epidemiology
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Summary:Objective: Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK. Methods: Population based case-control study nested in a cohort. Results: We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59-0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50-0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73-1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas. Conclusion: Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.
ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-005-4705-5