Prostate Cancer Risk among Men with Diabetes Mellitus (Spain)

Objective: Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK. Methods: Population based case-control study nested in a cohort. Results: We identified 2,183 incident...

Full description

Saved in:
Bibliographic Details
Published in:Cancer causes & control 2005-11, Vol.16 (9), p.1055-1058
Main Authors: González-Pérez, A., Rodríguez, L. A. García
Format: Article
Language:English
Subjects:
Aged
Antidiabetics
Cancer therapies
Case-Control Studies
Cell division
Databases as Topic
Diabetes
Diabetes complications
Diabetes mellitus
Diabetes Mellitus - drug therapy
Family Practice
General practice
Humans
Hypoglycemic agents
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Incidence
Insulin
Insulin-like growth factors
Male
Medical referrals
Patient admissions
Practice research
Prostate cancer
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - prevention & control
Risk
Risk Assessment
Risk Factors
Type 1 diabetes mellitus
Type 2 diabetes mellitus
United Kingdom - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c379t-d40c051b1dc5768a294d6191eb61887af7b0701de680ca8077a4b8385a7b553a3
cites cdi_FETCH-LOGICAL-c379t-d40c051b1dc5768a294d6191eb61887af7b0701de680ca8077a4b8385a7b553a3
container_end_page 1058
container_issue 9
container_start_page 1055
container_title Cancer causes & control
container_volume 16
creator González-Pérez, A.
Rodríguez, L. A. García
description Objective: Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK. Methods: Population based case-control study nested in a cohort. Results: We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59-0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50-0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73-1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas. Conclusion: Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.
doi_str_mv 10.1007/s10552-005-4705-5
format article
fullrecord <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_68620596</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>20069558</jstor_id><sourcerecordid>20069558</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-d40c051b1dc5768a294d6191eb61887af7b0701de680ca8077a4b8385a7b553a3</originalsourceid><addsrcrecordid>eNqFkUtLxDAUhYMozjj6A1woxYXoonqT9CbpwoWMTxhRfKxD2ma047Qdkxbx35uhg4IbNwkk37mPcwjZpXBCAeSpp4DIYgCMExkOXCNDipLHkjFcJ0NIUcbIEj4gW97PIICCwSYZUEFVEiRDcvbgGt-a1kZjU-fWRY-lf49M1dSv0Z2to8-yfYsuSpPZ1vrwMp-Xbeejo6eFKevjbbIxNXNvd1b3iLxcXT6Pb-LJ_fXt-HwS51ymbVwkkAPSjBY5SqEMS5NC0JTaLMyhpJnKDCTQwgoFuVEgpUkyxRUamSFyw0fksK-7cM1HZ32rq9LnYRhT26bzWqiwF6biX5CBDB0FDeDBH3DWdK4OS2hGOSAgwwDRHsqDSd7ZqV64sjLuS1PQywR0n4AOxuplAnqp2V8V7rLKFr-KleUB2OuBmW8b9_PPAESKqPg3IaGHSg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213050525</pqid></control><display><type>article</type><title>Prostate Cancer Risk among Men with Diabetes Mellitus (Spain)</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>Springer Nature</source><creator>González-Pérez, A. ; Rodríguez, L. A. García</creator><creatorcontrib>González-Pérez, A. ; Rodríguez, L. A. García</creatorcontrib><description>Objective: Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK. Methods: Population based case-control study nested in a cohort. Results: We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59-0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50-0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73-1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas. Conclusion: Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/s10552-005-4705-5</identifier><identifier>PMID: 16184470</identifier><identifier>CODEN: CCCNEN</identifier><language>eng</language><publisher>Netherlands: Kluwer Academic Publishers</publisher><subject>Aged ; Antidiabetics ; Cancer therapies ; Case-Control Studies ; Cell division ; Databases as Topic ; Diabetes ; Diabetes complications ; Diabetes mellitus ; Diabetes Mellitus - drug therapy ; Family Practice ; General practice ; Humans ; Hypoglycemic agents ; Hypoglycemic Agents - pharmacology ; Hypoglycemic Agents - therapeutic use ; Incidence ; Insulin ; Insulin-like growth factors ; Male ; Medical referrals ; Patient admissions ; Practice research ; Prostate cancer ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - prevention &amp; control ; Risk ; Risk Assessment ; Risk Factors ; Type 1 diabetes mellitus ; Type 2 diabetes mellitus ; United Kingdom - epidemiology</subject><ispartof>Cancer causes &amp; control, 2005-11, Vol.16 (9), p.1055-1058</ispartof><rights>Copyright 2005 Springer</rights><rights>Springer 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-d40c051b1dc5768a294d6191eb61887af7b0701de680ca8077a4b8385a7b553a3</citedby><cites>FETCH-LOGICAL-c379t-d40c051b1dc5768a294d6191eb61887af7b0701de680ca8077a4b8385a7b553a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/20069558$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/20069558$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16184470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González-Pérez, A.</creatorcontrib><creatorcontrib>Rodríguez, L. A. García</creatorcontrib><title>Prostate Cancer Risk among Men with Diabetes Mellitus (Spain)</title><title>Cancer causes &amp; control</title><addtitle>Cancer Causes Control</addtitle><description>Objective: Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK. Methods: Population based case-control study nested in a cohort. Results: We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59-0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50-0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73-1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas. Conclusion: Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.</description><subject>Aged</subject><subject>Antidiabetics</subject><subject>Cancer therapies</subject><subject>Case-Control Studies</subject><subject>Cell division</subject><subject>Databases as Topic</subject><subject>Diabetes</subject><subject>Diabetes complications</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - drug therapy</subject><subject>Family Practice</subject><subject>General practice</subject><subject>Humans</subject><subject>Hypoglycemic agents</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Incidence</subject><subject>Insulin</subject><subject>Insulin-like growth factors</subject><subject>Male</subject><subject>Medical referrals</subject><subject>Patient admissions</subject><subject>Practice research</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - prevention &amp; control</subject><subject>Risk</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Type 1 diabetes mellitus</subject><subject>Type 2 diabetes mellitus</subject><subject>United Kingdom - epidemiology</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqFkUtLxDAUhYMozjj6A1woxYXoonqT9CbpwoWMTxhRfKxD2ma047Qdkxbx35uhg4IbNwkk37mPcwjZpXBCAeSpp4DIYgCMExkOXCNDipLHkjFcJ0NIUcbIEj4gW97PIICCwSYZUEFVEiRDcvbgGt-a1kZjU-fWRY-lf49M1dSv0Z2to8-yfYsuSpPZ1vrwMp-Xbeejo6eFKevjbbIxNXNvd1b3iLxcXT6Pb-LJ_fXt-HwS51ymbVwkkAPSjBY5SqEMS5NC0JTaLMyhpJnKDCTQwgoFuVEgpUkyxRUamSFyw0fksK-7cM1HZ32rq9LnYRhT26bzWqiwF6biX5CBDB0FDeDBH3DWdK4OS2hGOSAgwwDRHsqDSd7ZqV64sjLuS1PQywR0n4AOxuplAnqp2V8V7rLKFr-KleUB2OuBmW8b9_PPAESKqPg3IaGHSg</recordid><startdate>20051101</startdate><enddate>20051101</enddate><creator>González-Pérez, A.</creator><creator>Rodríguez, L. A. García</creator><general>Kluwer Academic Publishers</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20051101</creationdate><title>Prostate Cancer Risk among Men with Diabetes Mellitus (Spain)</title><author>González-Pérez, A. ; Rodríguez, L. A. García</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-d40c051b1dc5768a294d6191eb61887af7b0701de680ca8077a4b8385a7b553a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Antidiabetics</topic><topic>Cancer therapies</topic><topic>Case-Control Studies</topic><topic>Cell division</topic><topic>Databases as Topic</topic><topic>Diabetes</topic><topic>Diabetes complications</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - drug therapy</topic><topic>Family Practice</topic><topic>General practice</topic><topic>Humans</topic><topic>Hypoglycemic agents</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Incidence</topic><topic>Insulin</topic><topic>Insulin-like growth factors</topic><topic>Male</topic><topic>Medical referrals</topic><topic>Patient admissions</topic><topic>Practice research</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Prostatic Neoplasms - prevention &amp; control</topic><topic>Risk</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Type 1 diabetes mellitus</topic><topic>Type 2 diabetes mellitus</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González-Pérez, A.</creatorcontrib><creatorcontrib>Rodríguez, L. A. García</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer causes &amp; control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González-Pérez, A.</au><au>Rodríguez, L. A. García</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostate Cancer Risk among Men with Diabetes Mellitus (Spain)</atitle><jtitle>Cancer causes &amp; control</jtitle><addtitle>Cancer Causes Control</addtitle><date>2005-11-01</date><risdate>2005</risdate><volume>16</volume><issue>9</issue><spage>1055</spage><epage>1058</epage><pages>1055-1058</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><coden>CCCNEN</coden><abstract>Objective: Observational studies have associated diabetes with a decreased risk of prostate cancer. We aimed to evaluate this association using the General Practitioner Research Database in the UK. Methods: Population based case-control study nested in a cohort. Results: We identified 2,183 incident cases of prostate cancer between January 1995 and December 2001. We found that diabetic patients had a decreased risk of prostate cancer (OR = 0.72; 95% CI: 0.59-0.87). This association was observed among treated diabetics (OR = 0.63; 95% CI: 0.50-0.80) but not among untreated diabetics (OR = 1.01; 95% CI: 0.73-1.40). Our results suggest that the observed reduced risk could be restricted to users of insulin or sulphonylureas. Conclusion: Patients with diabetes have a decreased risk of prostate cancer. The role of antidiabetic treatment in this association warrants further research.</abstract><cop>Netherlands</cop><pub>Kluwer Academic Publishers</pub><pmid>16184470</pmid><doi>10.1007/s10552-005-4705-5</doi><tpages>4</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0957-5243
ispartof Cancer causes & control, 2005-11, Vol.16 (9), p.1055-1058
issn 0957-5243
1573-7225
language eng
recordid cdi_proquest_miscellaneous_68620596
source JSTOR Archival Journals and Primary Sources Collection; Springer Nature
subjects Aged
Antidiabetics
Cancer therapies
Case-Control Studies
Cell division
Databases as Topic
Diabetes
Diabetes complications
Diabetes mellitus
Diabetes Mellitus - drug therapy
Family Practice
General practice
Humans
Hypoglycemic agents
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Incidence
Insulin
Insulin-like growth factors
Male
Medical referrals
Patient admissions
Practice research
Prostate cancer
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - prevention & control
Risk
Risk Assessment
Risk Factors
Type 1 diabetes mellitus
Type 2 diabetes mellitus
United Kingdom - epidemiology
title Prostate Cancer Risk among Men with Diabetes Mellitus (Spain)
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T01%3A48%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prostate%20Cancer%20Risk%20among%20Men%20with%20Diabetes%20Mellitus%20(Spain)&rft.jtitle=Cancer%20causes%20&%20control&rft.au=Gonz%C3%A1lez-P%C3%A9rez,%20A.&rft.date=2005-11-01&rft.volume=16&rft.issue=9&rft.spage=1055&rft.epage=1058&rft.pages=1055-1058&rft.issn=0957-5243&rft.eissn=1573-7225&rft.coden=CCCNEN&rft_id=info:doi/10.1007/s10552-005-4705-5&rft_dat=%3Cjstor_proqu%3E20069558%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c379t-d40c051b1dc5768a294d6191eb61887af7b0701de680ca8077a4b8385a7b553a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=213050525&rft_id=info:pmid/16184470&rft_jstor_id=20069558&rfr_iscdi=true