Insulin sensitivity: Gender-related differences in subjects with normal glucose tolerance

To verify whether age and the perimenopausal state may herald the onset of the metabolic syndrome (MS) in females as compared to age-matched males, we studied subjects with normal glucose tolerance, according to ADA definition. In 368 eligible subjects subdivided into three age groups we measured in...

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Published in:Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2006-07, Vol.16 (5), p.339-344
Main Authors: Schianca, G.P. Carnevale, Castello, L., Rapetti, R., Limoncini, A., Bartoli, E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Age Factors
Aged
Blood Glucose - metabolism
Body Mass Index
Cardiovascular disease
Female
Gender
Glucose Tolerance Test
Humans
Insulin - metabolism
Insulin Resistance
Male
Menopause
Menopause - metabolism
Metabolic Syndrome - blood
Metabolic Syndrome - epidemiology
Middle Aged
Risk Factors
Sex Factors
Waist-Hip Ratio
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Summary:To verify whether age and the perimenopausal state may herald the onset of the metabolic syndrome (MS) in females as compared to age-matched males, we studied subjects with normal glucose tolerance, according to ADA definition. In 368 eligible subjects subdivided into three age groups we measured insulin sensitivity by ISI-glycaemia, resistance by HOMA-IR, computed, during OGTT, from fasting and 2-h post-load plasma insulin and glucose concentrations. The significance of differences was tested between different age groups and between males and females within corresponding age groups. Insulin sensitivity fell slightly and insulin resistance rose significantly in the perimenopausal group as compared to younger and older female patients, and compared to men of the same age. This pattern remains after excluding patients with high blood pressure, and after adjusting for WHR and BMI by multivariate analysis. HOMA-IR averaged 2.9±1.8 in females, 2.2±1.2 in men aged 45–54 years ( p
ISSN:0939-4753
1590-3729
DOI:10.1016/j.numecd.2005.05.004