Asymmetric Synthesis of Active Pharmaceutical Ingredients

A review of asymmetric synthesis of active pharmaceutical ingredients is presented. The important trend toward single-enantiomer drugs is what has brought asymmetric synthesis to the forefront as a theme in drug discovery and development.

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Bibliographic Details
Published in:Chemical reviews 2006-07, Vol.106 (7), p.2734-2793
Main Authors: Farina, Vittorio, Reeves, Jonathan T, Senanayake, Chris H, Song, Jinhua J
Format: Article
Language:English
Subjects:
Chemistry
Chemistry, Pharmaceutical - methods
Molecular Structure
Pharmaceutical industry
Pharmaceutical Preparations - chemical synthesis
Pharmaceutical Preparations - chemistry
Pharmacology
Process engineering
Stereoisomerism
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Description
Summary:A review of asymmetric synthesis of active pharmaceutical ingredients is presented. The important trend toward single-enantiomer drugs is what has brought asymmetric synthesis to the forefront as a theme in drug discovery and development.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr040700c