Alzheimer's disease pathology influences severity and topographical distribution of cerebral amyloid angiopathy

Cerebral amyloid angiopathy (CAA) is defined by beta-amyloid peptide (Abeta) depositions in cerebral vessels and is associated with Alzheimer's disease (AD). The relationship between sporadic CAA and AD, and the origin of Abeta in CAA are poorly understood. The aim of our study was to investiga...

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Bibliographic Details
Published in:Acta neuropathologica 2005-09, Vol.110 (3), p.222-231
Main Authors: Attems, Johannes, Jellinger, Kurt A, Lintner, Felix
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Alzheimer Disease - physiopathology
Alzheimer's disease
Amyloid beta-Peptides - metabolism
Apolipoproteins E - genetics
Autopsies
Blood vessels
Brain - blood supply
Brain - pathology
Brain - physiopathology
Cerebral Amyloid Angiopathy - metabolism
Cerebral Amyloid Angiopathy - pathology
Cerebral Amyloid Angiopathy - physiopathology
Cerebral Arteries - metabolism
Cerebral Arteries - pathology
Cerebral Arteries - physiopathology
Dementia
Disease Progression
DNA Mutational Analysis
Female
Genetic Testing
Genotype
Genotype & phenotype
Humans
Immunohistochemistry
Male
Middle Aged
Neuropathology
Neurosciences
Occipital Lobe - blood supply
Occipital Lobe - pathology
Occipital Lobe - physiopathology
Pathology
Peptides
Plaque, Amyloid - metabolism
Plaque, Amyloid - pathology
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Summary:Cerebral amyloid angiopathy (CAA) is defined by beta-amyloid peptide (Abeta) depositions in cerebral vessels and is associated with Alzheimer's disease (AD). The relationship between sporadic CAA and AD, and the origin of Abeta in CAA are poorly understood. The aim of our study was to investigate the relationship between CAA and AD. Autopsy brains (n=113, 61.1% female, 55.8% clinically demented, age range 54-102 years, mean +/- SE 83.5+/-0.93 years) underwent standardized neuropathological assessment. CAA was evaluated in frontal, frontobasal, hippocampal, and occipital regions. Using immunohistochemistry, the severity of Abeta deposition in vessels was assessed semiquantitatively for each region separately. Evaluation of APOE genotype in 53 cases using real-time PCR showed significant correlations with severe AD pathology and CAA. CAA was present in 77 cases (68.1%), with the occipital region being affected significantly more often and more severely than other regions (P
ISSN:0001-6322
1432-0533
DOI:10.1007/s00401-005-1064-y