A Practical Mild, One-Pot, Regiospecific Synthesis of 2,3-Disubstituted Indoles via Consecutive Sonogashira and Cacchi Reactions

A practical one-pot, regiospecific three-component process for the synthesis of 2,3-disubstituted indoles was developed via consecutive Pd-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.

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Bibliographic Details
Published in:Organic letters 2006-07, Vol.8 (15), p.3271-3274
Main Authors: Lu, Bruce Z, Zhao, Wenyi, Wei, Han-Xun, Dufour, Marine, Farina, Vittorio, Senanayake, Chris H
Format: Article
Language:English
Subjects:
Catalysis
Combinatorial Chemistry Techniques
Indoles - chemical synthesis
Molecular Structure
Palladium - chemistry
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Description
Summary:A practical one-pot, regiospecific three-component process for the synthesis of 2,3-disubstituted indoles was developed via consecutive Pd-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol061136q