Shortcut method for evaluation and design of a hybrid process for enantioseparations

Hybrid processes for enantioseparations have a considerable potential for reducing investment and operational costs. An example is the combination of simulated moving bed (SMB) chromatography and selective crystallisation. However, the design of integrated processes is a difficult task. A shortcut m...

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Bibliographic Details
Published in:Journal of Chromatography A 2005-10, Vol.1092 (1), p.43-54
Main Authors: Kaspereit, Malte, Gedicke, Knut, Zahn, Volker, Mahoney, Alan W., Seidel-Morgenstern, Andreas
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Chirobiotic T
Chromatographic methods and physical methods associated with chromatography
Chromatography - methods
Crystallisation
Enantioseparation
Exact sciences and technology
Hybrid processes
Mandelic acid
Mass balance
Other chromatographic methods
Pharmaceutical Preparations - chemistry
Segregation factor
Shortcut method
SMB chromatography
Stereoisomerism
TMB
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Summary:Hybrid processes for enantioseparations have a considerable potential for reducing investment and operational costs. An example is the combination of simulated moving bed (SMB) chromatography and selective crystallisation. However, the design of integrated processes is a difficult task. A shortcut method is presented that can serve as a tool for design and estimation of the potential of such processes. The approach requires only limited experimental data and thus allows for systematic parameter studies. The method is based on the determination of the purity-performance characteristic of the SMB process and rigorous application of mass balances. The use of relative mass fluxes allows derivation of simple algebraic expressions for essential process parameters. The significant potential of combining SMB and crystallisation is demonstrated for the example of the separation of mandelic acid enantiomers.
ISSN:0021-9673
DOI:10.1016/j.chroma.2005.02.043