Helicobacter pylori protein oxidation influences the colonization process

Dsb proteins control the formation and rearrangement of disulfide bonds during the folding of membrane and exported proteins. Here we examined the role of DsbI protein in Helicobacter pylori pathogenesis and demonstrated that a dsbI mutant impaired in disulfide bond formation revealed a greatly redu...

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Bibliographic Details
Published in:International journal of medical microbiology 2006-08, Vol.296 (4), p.321-324
Main Authors: Godlewska, Renata, Dzwonek, Artur, Mikuła, Michał, Ostrowski, Jerzy, Pawłowski, Marcin, Bujnicki, Janusz M., Jagusztyn-Krynicka, Elżbieta K.
Format: Article
Language:English
Subjects:
Animals
Colonization
Disease Models, Animal
Gastric Mucosa - microbiology
Helicobacter Infections - microbiology
Helicobacter pylori
Helicobacter pylori - genetics
Helicobacter pylori - metabolism
Helicobacter pylori - pathogenicity
Mice
Mice, Inbred C57BL
Oxidation-Reduction
Protein Disulfide-Isomerases - genetics
Protein Disulfide-Isomerases - metabolism
Protein oxidation
Virulence - genetics
Virulence Factors - genetics
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Summary:Dsb proteins control the formation and rearrangement of disulfide bonds during the folding of membrane and exported proteins. Here we examined the role of DsbI protein in Helicobacter pylori pathogenesis and demonstrated that a dsbI mutant impaired in disulfide bond formation revealed a greatly reduced ability to colonize mice gastric mucosa.
ISSN:1438-4221
1618-0607
DOI:10.1016/j.ijmm.2005.11.010