Binding Aedes aegypti densonucleosis virus to ion exchange membranes

Experimental and numerical results for binding Aedes aegypti densonucleosis virus (AeDNV) using anion and cation exchange membranes are presented. AeDNV particles are adsorbed by anion and cation exchange membranes providing the virus particles and membranes are oppositely charged. Q membranes which...

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Bibliographic Details
Published in:Journal of Chromatography A 2005-10, Vol.1092 (1), p.114-124
Main Authors: Han, Binbing, Specht, Rachel, Wickramasinghe, S. Ranil, Carlson, Jonathan O.
Format: Article
Language:English
Subjects:
Adsorptive membranes
Aedes - virology
Aedes aegypti densonucleosis virus
Animals
Biological and medical sciences
Densovirinae - physiology
Fundamental and applied biological sciences. Psychology
Ion exchange membrane
Ion Exchange Resins
Membrane chromatography
Membranes, Artificial
Microbiology
Techniques used in virology
Virology
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Summary:Experimental and numerical results for binding Aedes aegypti densonucleosis virus (AeDNV) using anion and cation exchange membranes are presented. AeDNV particles are adsorbed by anion and cation exchange membranes providing the virus particles and membranes are oppositely charged. Q membranes which are strongly basic anion exchangers were the most effective. Dynamic and static capacities for Q membranes were found to be similar. A numerical model is proposed which assumes a log normal pore size distribution. By estimating the required parameters from static binding experiments, the model may be used to calculate the breakthrough curve for virus adsorption.
ISSN:0021-9673
DOI:10.1016/j.chroma.2005.06.089