Global distribution of TEM-1 and ROB-1 β-lactamases in Haemophilus influenzae

Objectives: To determine the global distribution of TEM-1 and ROB-1 β-lactamases in Haemophilus influenzae isolated from patients with community-acquired respiratory tract infection during the first 4 years of the PROTEKT study (1999–2003). To investigate the activities of commonly used antibiotics...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2005-10, Vol.56 (4), p.773-776
Main Authors: Farrell, D. J., Morrissey, I., Bakker, S., Buckridge, S., Felmingham, D.
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
beta-Lactamases - analysis
beta-Lactamases - metabolism
Biological and medical sciences
cefaclor
cefprozil
Global Health
Haemophilus influenzae
Haemophilus influenzae - enzymology
Haemophilus influenzae - genetics
Helicobacter Infections - epidemiology
Helicobacter Infections - microbiology
Humans
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
resistance genes
Respiratory Tract Infections - microbiology
surveillance
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Summary:Objectives: To determine the global distribution of TEM-1 and ROB-1 β-lactamases in Haemophilus influenzae isolated from patients with community-acquired respiratory tract infection during the first 4 years of the PROTEKT study (1999–2003). To investigate the activities of commonly used antibiotics against these isolates. Methods: For 14 870 H. influenzae, MIC testing was performed using NCCLS broth microdilution methodology. For 2225 β-lactamase-positive (BLP) H. influenzae, TEM-1 and ROB-1 genes were detected using a Taqman PCR method. Results: β-Lactamase positivity was 15.0% overall but varied greatly by country (
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dki281