Relation of Microalbuminuria to Adiponectin and Augmented C-Reactive Protein Levels in Men With Essential Hypertension

Microalbuminuria, and recently, hypoadiponectinemia, have been associated with progression of atherosclerotic disease and increased cardiovascular risk. We examined the possible associations of urinary albumin excretion, expressed as the ratio of albumin to creatinine (ACR), with plasma adiponectin...

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Bibliographic Details
Published in:The American journal of cardiology 2005-10, Vol.96 (7), p.946-951
Main Authors: Tsioufis, Costas, Dimitriadis, Kyriakos, Chatzis, Dimitris, Vasiliadou, Carmen, Tousoulis, Dimitrios, Papademetriou, Vasilios, Toutouzas, Pavlos, Stefanadis, Christodoulos, Kallikazaros, Ioannis
Format: Article
Language:English
Subjects:
Adiponectin
Adult
Aged
Albuminuria - urine
Biological and medical sciences
C-Reactive Protein - analysis
Cardiology
Cardiovascular disease
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Humans
Hypertension
Hypertension - blood
Intercellular Signaling Peptides and Proteins - blood
Male
Medical sciences
Men
Middle Aged
Nephrology. Urinary tract diseases
Proteins
Risk Factors
Urinary system involvement in other diseases. Miscellaneous
Urinary tract. Prostate gland
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Summary:Microalbuminuria, and recently, hypoadiponectinemia, have been associated with progression of atherosclerotic disease and increased cardiovascular risk. We examined the possible associations of urinary albumin excretion, expressed as the ratio of albumin to creatinine (ACR), with plasma adiponectin and high-sensitivity C-reactive protein (hs-CRP) levels in men who had essential hypertension. The study population consisted of 108 men who did not have diabetes and were newly diagnosed with stage I to II essential hypertension (age 44.6 years, office blood pressure 148/95 mm Hg) and 110 men matched according to age and body mass index as controls. According to ACR values, which were determined as the average of 2 nonconsecutive overnight spot urine samples, subjects who had hypertension were categorized into 2 groups: those who had microalbuminuria (n = 28; mean ACR 30 to 300 mg/g) and those who had normal albuminuria (n = 80; mean ACR
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2005.05.052