Polyunsaturated fatty acids in plasma lipids of diabetic children during and after diabetic ketoacidosis

• Published in: Acta pædiatrica (Oslo) 2005-07, Vol.94 (7), p.850-855
• Main Authors: DECSI, Tamas, SZABO, Eva, KOZARI, Adrienn, ERHARDT, Eva, MAROSVÖLGYI, Tamas, SOLTESZ, Gyula
• Format: Article
• Language: English
• Subjects: Adolescent; Biological and medical sciences; Diabetes. Impaired glucose tolerance; Diabetic Ketoacidosis - blood; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fatty Acids, Unsaturated - blood; Female; General aspects; Humans; Linoleic Acid - blood; Male; Medical sciences; Phospholipids - chemistry
• ISSN: 0803-5253; 1651-2227
• DOI: 10.1080/08035250510028254

Previously we reported significantly higher plasma values of the essential fatty acids but significantly lower values of their longer-chain metabolites in diabetic children than in healthy controls. Here, we report data on the acute effect of diabetic ketoacidosis (DKA) on the fatty acid composition of plasma lipids. Diabetic children (n=9; age: 16.1 [3.3] y; duration of diabetes: 5.0 [5.3.] y; daily insulin dose: 0.87 [0.66] unit/kg body weight/d; glycated haemoglobin: 13.4 [2.8] %; median [IQR]) were investigated at admission for DKA (during DKA) and at the end of the treatment of DKA (after DKA). Fatty acid composition of plasma lipid classes was determined by high-resolution capillary gas-liquid chromatography. Blood glucose (27.0 [8.5] vs 6.5 [1.6] mmol/l), pH (7.28 [0.35] vs 7.36 [0.06]) and base excess (-8.9 [15.1] vs -2.2 [6.3] mmol/l) were grossly abnormal during but not after DKA. Values of linoleic acid were significantly lower after than during DKA (non-esterifed fatty acids (NEFA): 15.55 [1.47] vs 12.27 [5.74] % wt/wt; triacylglycerols (TG): 20.84 [9.23] vs 17.40 [5.78]; p