Polyunsaturated fatty acids in plasma lipids of diabetic children during and after diabetic ketoacidosis

Previously we reported significantly higher plasma values of the essential fatty acids but significantly lower values of their longer-chain metabolites in diabetic children than in healthy controls. Here, we report data on the acute effect of diabetic ketoacidosis (DKA) on the fatty acid composition...

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Published in:Acta pædiatrica (Oslo) 2005-07, Vol.94 (7), p.850-855
Main Authors: DECSI, Tamas, SZABO, Eva, KOZARI, Adrienn, ERHARDT, Eva, MAROSVÖLGYI, Tamas, SOLTESZ, Gyula
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Diabetes. Impaired glucose tolerance
Diabetic Ketoacidosis - blood
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fatty Acids, Unsaturated - blood
Female
General aspects
Humans
Linoleic Acid - blood
Male
Medical sciences
Phospholipids - chemistry
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cited_by cdi_FETCH-LOGICAL-c329t-ca4f8d05230025d3f79bbbe8e460390ab256397555a6fc686960be47f7397bb03
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container_title Acta pædiatrica (Oslo)
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creator DECSI, Tamas
SZABO, Eva
KOZARI, Adrienn
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MAROSVÖLGYI, Tamas
SOLTESZ, Gyula
description Previously we reported significantly higher plasma values of the essential fatty acids but significantly lower values of their longer-chain metabolites in diabetic children than in healthy controls. Here, we report data on the acute effect of diabetic ketoacidosis (DKA) on the fatty acid composition of plasma lipids. Diabetic children (n=9; age: 16.1 [3.3] y; duration of diabetes: 5.0 [5.3.] y; daily insulin dose: 0.87 [0.66] unit/kg body weight/d; glycated haemoglobin: 13.4 [2.8] %; median [IQR]) were investigated at admission for DKA (during DKA) and at the end of the treatment of DKA (after DKA). Fatty acid composition of plasma lipid classes was determined by high-resolution capillary gas-liquid chromatography. Blood glucose (27.0 [8.5] vs 6.5 [1.6] mmol/l), pH (7.28 [0.35] vs 7.36 [0.06]) and base excess (-8.9 [15.1] vs -2.2 [6.3] mmol/l) were grossly abnormal during but not after DKA. Values of linoleic acid were significantly lower after than during DKA (non-esterifed fatty acids (NEFA): 15.55 [1.47] vs 12.27 [5.74] % wt/wt; triacylglycerols (TG): 20.84 [9.23] vs 17.40 [5.78]; p
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Here, we report data on the acute effect of diabetic ketoacidosis (DKA) on the fatty acid composition of plasma lipids. Diabetic children (n=9; age: 16.1 [3.3] y; duration of diabetes: 5.0 [5.3.] y; daily insulin dose: 0.87 [0.66] unit/kg body weight/d; glycated haemoglobin: 13.4 [2.8] %; median [IQR]) were investigated at admission for DKA (during DKA) and at the end of the treatment of DKA (after DKA). Fatty acid composition of plasma lipid classes was determined by high-resolution capillary gas-liquid chromatography. Blood glucose (27.0 [8.5] vs 6.5 [1.6] mmol/l), pH (7.28 [0.35] vs 7.36 [0.06]) and base excess (-8.9 [15.1] vs -2.2 [6.3] mmol/l) were grossly abnormal during but not after DKA. Values of linoleic acid were significantly lower after than during DKA (non-esterifed fatty acids (NEFA): 15.55 [1.47] vs 12.27 [5.74] % wt/wt; triacylglycerols (TG): 20.84 [9.23] vs 17.40 [5.78]; p&lt;0.05). In contrast, values of gamma-linolenic acid (NEFA: 0.87 [0.54] vs 2.34 [1.85]; p&lt;0.05) and arachidonic acid (TG: 1.37 [0.71] vs 1.74 [0.57]; p&lt;0.05) were significantly lower during than after DKA. The product/substrate ratios for delta-6 desaturation were significantly lower during than after DKA. Successful treatment of diabetic ketoacidosis is associated with a significant increase of long-chain polyunsaturated fatty acid values in blood plasma in diabetic children. This observation suggests that disturbances of essential fatty acid metabolism in diabetic children are related not only to diet but to hypoinsulinaemia as well.</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>16188805</pmid><doi>10.1080/08035250510028254</doi><tpages>6</tpages></addata></record>
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ispartof Acta pædiatrica (Oslo), 2005-07, Vol.94 (7), p.850-855
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1651-2227
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source Wiley-Blackwell Read & Publish Collection
subjects Adolescent
Biological and medical sciences
Diabetes. Impaired glucose tolerance
Diabetic Ketoacidosis - blood
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Fatty Acids, Unsaturated - blood
Female
General aspects
Humans
Linoleic Acid - blood
Male
Medical sciences
Phospholipids - chemistry
title Polyunsaturated fatty acids in plasma lipids of diabetic children during and after diabetic ketoacidosis
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