No relationship of -627 interleukin-10 promoter polymorphism in Chinese patients with rheumatoid arthritis

The aim of this study was to examine whether -627 interleukin-10 (IL-10) promoter polymorphism is a marker of susceptibility to or severity of rheumatoid arthritis (RA) in Chinese patients in Taiwan. The study included 198 Chinese patients with RA. One hundred unrelated healthy individuals living in...

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Bibliographic Details
Published in:Rheumatology international 2005-10, Vol.25 (8), p.576-579
Main Authors: HUANG, Chung-Ming, TSAI, Chang-Hai, CHEN, Chi-Lan, CHANG, Chin-Ping, TSAI, Fuu-Jen
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Rheumatoid - ethnology
Arthritis, Rheumatoid - genetics
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Diseases of the osteoarticular system
Female
Humans
Inflammatory joint diseases
Interleukin-10 - genetics
Male
Medical sciences
Middle Aged
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
Rheumatoid arthritis
Taiwan - ethnology
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Summary:The aim of this study was to examine whether -627 interleukin-10 (IL-10) promoter polymorphism is a marker of susceptibility to or severity of rheumatoid arthritis (RA) in Chinese patients in Taiwan. The study included 198 Chinese patients with RA. One hundred unrelated healthy individuals living in central Taiwan served as the control subjects. The relationship between IL-10 gene polymorphism and clinical manifestations of RA was evaluated. For the genotype, allelic frequency, and carriage rate of IL-10 polymorphism, there were no statistically significant differences found between patients and controls. Furthermore, we did not detect any association of IL-10 genotype with rheumatoid factor (RF), extra-articular involvement, or bone erosion in the RA patients. The lack of association of -627 IL-10 gene polymorphism with RA and the clinical findings in our study implies that the IL-10 gene polymorphism cannot serve as a candidate gene marker for screening RA patients.
ISSN:0172-8172
1437-160X
DOI:10.1007/s00296-004-0480-y