Long-term hemorrhage risk in children versus adults with brain arteriovenous malformations

Children with brain arteriovenous malformations (BAVMs) are said to be at higher risk for intracranial hemorrhage (ICH) than adults. Although this notion affects treatment decisions, the evidence to support this claim is limited. To compare the risk of ICH in children versus adults with BAVM, we stu...

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Bibliographic Details
Published in:Stroke (1970) 2005-10, Vol.36 (10), p.2099-2104
Main Authors: FULLERTON, Heather J, ACHROL, Achal S, JOHNSTON, S. Claiborne, MCCULLOCH, Charles E, HIGASHIDA, Randall T, LAWTON, Michael T, SIDNEY, Stephen, YOUNG, William L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Biological and medical sciences
Cerebral Hemorrhage - diagnosis
Cerebral Hemorrhage - epidemiology
Cerebral Hemorrhage - etiology
Child
Child, Preschool
Cohort Studies
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Female
Follow-Up Studies
Humans
Intracranial Arteriovenous Malformations - complications
Intracranial Arteriovenous Malformations - diagnosis
Intracranial Arteriovenous Malformations - epidemiology
Intracranial Arteriovenous Malformations - pathology
Male
Medical sciences
Middle Aged
Neurology
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Non tumoral diseases
Odds Ratio
Otorhinolaryngology. Stomatology
Pharmacology. Drug treatments
Proportional Hazards Models
Risk
Sensitivity and Specificity
Serotoninergic system
Survivors
Time Factors
Treatment Outcome
Vascular diseases and vascular malformations of the nervous system
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Summary:Children with brain arteriovenous malformations (BAVMs) are said to be at higher risk for intracranial hemorrhage (ICH) than adults. Although this notion affects treatment decisions, the evidence to support this claim is limited. To compare the risk of ICH in children versus adults with BAVM, we studied all cases of BAVM evaluated at the University of California, San Francisco (January 2000 to December 2004; n=400) and Kaiser Permanente Northern California (January 1993 to December 2004; n=819). In Kaplan-Meier survival analyses, the index date was the date of initial BAVM detection; cases were censored at time of subsequent ICH (the primary outcome, defined as ICH after initial presentation), first BAVM treatment, or loss to follow-up. Cox proportional hazards models included childhood presentation (
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000181746.77149.2b