Nuclear inositol lipid metabolism: More than just second messenger generation?

A distinct polyphosphoinositide cycle is present in the nucleus, and growing evidence suggests its importance in DNA replication, gene transcription, and apoptosis. Even though it was initially thought that nuclear inositol lipids would function as a source for second messengers, recent findings str...

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Bibliographic Details
Published in:Journal of cellular biochemistry 2005-10, Vol.96 (2), p.285-292
Main Authors: Martelli, Alberto M., Follo, Matilde Yung, Evangelisti, Camilla, Falà, Federica, Fiume, Roberta, Billi, Anna Maria, Cocco, Lucio
Format: Article
Language:English
Subjects:
5)P2
Animals
apoptosis
Cell Nucleus - metabolism
Chromatin - metabolism
chromatin organization
Humans
Inositol - metabolism
Isoenzymes - metabolism
Lipid Metabolism
myelodisplastic syndrome
nucleus
phosphoinositide 3-kinase
phospholipase C
Phospholipase C beta
PtdIns
PtdIns(4,5)P2
Second Messenger Systems
Type C Phospholipases - metabolism
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Summary:A distinct polyphosphoinositide cycle is present in the nucleus, and growing evidence suggests its importance in DNA replication, gene transcription, and apoptosis. Even though it was initially thought that nuclear inositol lipids would function as a source for second messengers, recent findings strongly indicate that lipids present in the nucleus also fulfil other roles. The scope of this review is to highlight the most intriguing advances made in the field over the last few years, such as the possibility that nuclear phosphatidylinositol (4,5) bisphosphate is involved in maintaining chromatin in a transcriptionally active conformation, the new emerging roles for intranuclear phosphatidylinositol (3,4,5) trisphosphate and phosphoinositide 3‐kinase, and the evidence which suggests a tight relationship between a decreased level of nuclear phosphoinositide specific phospholipase C‐β1 and the evolution of myelodisplastic syndrome into acute myeloid leukemia. © 2005 Wiley‐Liss, Inc.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.20527