Isolated Hypertriglyceridemia: An Insulin-Resistant State with or without Low HDL Cholesterol

There are numerous reports on insulin resistance in subjects with hypertriglyceridemia but most of the studies involved obese or diabetic subjects. We were interested to study such events but in a population free from other confounders influencing insulin sensitivity (i.e., obesity, glucose intolera...

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Bibliographic Details
Published in:Journal of Atherosclerosis and Thrombosis 2006, Vol.13(3), pp.143-148
Main Authors: Al-Mahmood, AK, Ismail, AA, Rashid, FA, Mohamed, Wan
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Cholesterol, HDL - blood
Cross-Sectional Studies
Female
Homeostasis model assessment (HOMA)
Humans
Hypertriglyceridemia - complications
Insulin - metabolism
Insulin Resistance
Insulin Secretion
Insulin secretory status
Insulin sensitivity
Male
Middle Aged
Risk Factors
Software
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Summary:There are numerous reports on insulin resistance in subjects with hypertriglyceridemia but most of the studies involved obese or diabetic subjects. We were interested to study such events but in a population free from other confounders influencing insulin sensitivity (i.e., obesity, glucose intolerance and hypertension). From the population of a cross-sectional study we obtained 12 subjects with isolated hypertriglyceridemia and compared their insulin sensitivity with that of normolipidemic subjects in that study. Insulin sensitivity and secretory status were computed using homeostasis model assessment (HOMA) software. The insulin sensitivity of hypertriglyceridemic subjects was found to be lower than in normolipidemic subjects. For the hypertriglyceridemic subjects, insulin sensitivity (HOMA%S) was 60.07% (values adjusted for age, BMI, waist circumference, and cholesterol levels), which was substantially lower than that of normolipidemic subjects (150.03%; p
ISSN:1340-3478
1880-3873
DOI:10.5551/jat.13.143