Association of Phosphodiesterase 4D gene with ischemic stroke in a pakistani population

Identification of STRK1 locus by the deCODE group followed by the discovery of phosphodiesterase 4D (PDE4D) gene in strong association with ischemic stroke patients has provided useful insights toward understanding the genetic etiology of the disease. In this study, we aimed at investigating the ass...

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Bibliographic Details
Published in:Stroke (1970) 2005-10, Vol.36 (10), p.2275-2277
Main Authors: SALEHEEN, Danish, BUKHARI, Shabbar, HAIDER, Shajjia Razi, NAZIR, Aisha, KHANUM, Shaheen, SHAFQAT, Saad, KASHIF ANIS, M, FROSSARD, Philippe
Format: Article
Language:English
Subjects:
3',5'-Cyclic-AMP Phosphodiesterases - genetics
Aged
Alleles
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Brain - pathology
Brain Ischemia - genetics
Brain Ischemia - pathology
Case-Control Studies
Cyclic Nucleotide Phosphodiesterases, Type 3
Cyclic Nucleotide Phosphodiesterases, Type 4
DNA Primers - chemistry
Female
Genetic Markers
Genetic Predisposition to Disease
Genetic Variation
Genetics, Population
Genotype
Haplotypes
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Homozygote
Humans
Linkage Disequilibrium
Male
Medical sciences
Middle Aged
Models, Statistical
Multivariate Analysis
Nervous system (semeiology, syndromes)
Neurology
Odds Ratio
Pakistan
Pharmacology. Drug treatments
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Risk Factors
Stroke - enzymology
Stroke - genetics
Vascular diseases and vascular malformations of the nervous system
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Summary:Identification of STRK1 locus by the deCODE group followed by the discovery of phosphodiesterase 4D (PDE4D) gene in strong association with ischemic stroke patients has provided useful insights toward understanding the genetic etiology of the disease. In this study, we aimed at investigating the association between 3 polymorphisms of the PDE4D gene and ischemic stroke in the Pakistani population. Three polymorphisms in PDE4D gene were analyzed in 200 patients of ischemic stroke and 250 controls of Pakistani origin using polymerase chain reaction-restriction fragment length polymorphism method. Data were coded and entered in SPSS Windows (version 12.0). Odds ratios and 95% CIs were calculated using multivariate logistic regression analysis. Marker SNP83(rs966221) was found significantly associated with ischemic stroke on univariate and multivariate analysis (P
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000182242.59466.ee