Exaled nitric oxide and air trapping correlation in asthmatic children

Exhaled nitric oxide (eNO) levels have been shown to correlate with atopy and with airway hyperresponsiveness but not with standard spirometry. The aim of our study was to evaluate the correlation between eNo levels and functional residual capacity (FRC), residual volume (RV), RV to total lung capac...

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Bibliographic Details
Published in:Allergy (Copenhagen) 2005-11, Vol.60 (11), p.1436-1439
Main Authors: Mappa, L., Cardinale, F., Camodeca, R., Tortorella, M. L., Pietrobelli, A., Armenio, L., Boner, A. L.
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adolescent
Allergic diseases
asthma
Asthma - drug therapy
Asthma - physiopathology
Biological and medical sciences
Child
children
exhaled nitric oxide
Female
Functional Residual Capacity
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Hydroxycorticosteroids - administration & dosage
Immunopathology
Luminescent Measurements
Male
Medical sciences
Nitric Oxide - analysis
Nitric Oxide - metabolism
Plethysmography
Residual Volume
Vital Capacity
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Summary:Exhaled nitric oxide (eNO) levels have been shown to correlate with atopy and with airway hyperresponsiveness but not with standard spirometry. The aim of our study was to evaluate the correlation between eNo levels and functional residual capacity (FRC), residual volume (RV), RV to total lung capacity (TLC) ratio, and pulmonary resistances in asthmatic children ages 6–13 years. Forty‐nine patients (35 males) were enrolled in the study. Nineteen of them were not receiving inhaled corticosteroids. The eNO levels were measured by chemiluminescence's analyzer and lung function study were performed by body box plethysmography. As expected, there was no correlation between eNO levels and forced vital capacity (FVC); forced expiratory volume in the first second (FEV1); mid respiratory flow between 25 and 75% of the vital capacity (MEF25‐‐75), FEV1/FVC, and pulmonary resistances. Instead a correlation was found between eNO level and RV both considering all the study population together (r = 0.51, P = 0.001) and separately the asthmatic children not receiving ICS (r = 0.6, P = 0.003). In the patients receiving ICS the correlation was still present (r = 0.43, P = 0.01). The correlation between eNo levels and RV may reflect the effect of airway inflammation on NO production and diffusion as well as peripheral airway trapping and consequent RV.
ISSN:0105-4538
1398-9995
DOI:10.1111/j.1398-9995.2005.00905.x