Elevation of telomerase activity positively correlates to poor prognosis of patients with non-small cell lung cancer

• Published in: Cancer letters 2006-08, Vol.240 (1), p.148-156
• Main Authors: Chen, Kuan-Yu, Lee, Li-Na, Yu, Chong-Jen, Lee, Yung-Chie, Kuo, Sow-Hsong, Yang, Pan-Chyr
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Aging; Cancer therapies; Carcinoma, Non-Small-Cell Lung - enzymology; Carcinoma, Non-Small-Cell Lung - pathology; Classification; Female; Histology; Humans; Lung; Lung cancer; Lung Neoplasms - enzymology; Lung Neoplasms - pathology; Male; Malignancy; Medical prognosis; Middle Aged; Mortality; Neoplasm Recurrence, Local; Prognosis; Proportional Hazards Models; Proteins; Retrospective Studies; Surgery; Survival; Survival Analysis; Telomerase; Telomerase - analysis; Telomerase - metabolism; Tumors
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2005.09.005

Increased telomerase activity has been found in various types of human malignancies, including lung cancer. However, the correlation between the level of telomerase activity and the clinical characteristics of lung cancer patients remains unclear. The levels of telomerase activity in lung cancer specimens and adjacent non-neoplastic tissues obtained from 68 patients who underwent surgery were measured by using a non-radioactive quantitative method. Clinical and pathologic parameters were evaluated with respect to the level of telomerase activity. Prominent telomerase activity was detected in 58 (85.3%) lung cancer tissues and 21 (30.9%) adjacent non-neoplastic tissues. There was a trend of increase in relative telomerase activity in regard to the advanced pathological stage, and lymph node metastasis. Using Cox regression analysis, we found that every 100 unit of increase in relative telomerase activity was associated with an increase in the hazard ratio of death by 13% after controlling for other variables such as age, gender, and stage (Hazard ratio=1.13; 95% CI: 1.03–1.23, P=0.006). For patients with stage I disease, an increase of every 100 unit of relative telomerase activity was associated with an even higher increase of 33% in the hazard ratio of death (Hazard ratio=1.33; 95% CI: 1.07–1.65, P=0.011) and a 16% increase in the hazard of disease recurrence (Hazard ratio=1.16, 95% CI: 1.01–1.33, P=0.032). The level of telomerase activity is positively correlated with the risk of recurrence and mortality of lung cancer. The level of telomerase activity would predict the prognosis of lung cancer patients.