Incidence of anti-brain antibodies in children with obsessive–compulsive disorder

Obsessions and compulsions may occur in the post-streptococcal disorders Sydenham's chorea and paediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS). The proposed mediators are anti-basal ganglia antibodies (ABGA). We tested the hypothesis that post-streptococc...

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Bibliographic Details
Published in:British journal of psychiatry 2005-10, Vol.187 (4), p.314-319
Main Authors: Dale, Russell C., Heyman, Isobel, Giovannoni, Gavin, Church, Andrew J.
Format: Article
Language:English
Subjects:
Adolescent
Age
Antibodies
Antibodies - blood
Antibodies - immunology
Antigen-Antibody Reactions - immunology
Antigens
Attention deficit hyperactivity disorder
Autoantigens - immunology
Autoimmune disorders
Autoimmunity
Autoimmunity - immunology
Basal ganglia
Basal Ganglia - immunology
Blotting, Western - methods
Brain
Brain - immunology
Brain research
Central nervous system
Child
Child & adolescent psychiatry
Children
Children & youth
Chorea
Cohort Studies
Enzyme-linked immunosorbent assay
Enzyme-Linked Immunosorbent Assay - methods
Female
Humans
Hypotheses
Idiopathic
Immunoblotting
Immunoglobulins
Infections
Investigations
Laboratories
Male
Males
Mental disorders
Nervous system
Neuropsychiatry
Neurosciences
Obsessive compulsive disorder
Obsessive-Compulsive Disorder - immunology
Obsessive-Compulsive neuroses
Proteins
Psychiatry
Sick children
Streptococcal Infections - immunology
Streptococcus infections
SYDENHAM'S_CHOREA
Tourette syndrome
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Description
Summary:Obsessions and compulsions may occur in the post-streptococcal disorders Sydenham's chorea and paediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS). The proposed mediators are anti-basal ganglia antibodies (ABGA). We tested the hypothesis that post-streptococcal autoimmunity may have a role in'idiopathic'obsessive-compulsive disorder (OCD). We examined 50 children with OCD for ABGA using enzyme-linked immunosorbent assay (ELISA) and western immunoblotting. The findings were compared with paediatric autoimmune (n=50), neurological (n=100) and streptococcal (n=40) controls. The mean ABGA binding on ABGA binding on ELISA was elevated in the patient cohort compared with all control groups (P
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.187.4.314