Successful Treatment of Localized Cutaneous Infection Caused by Mycobacterium scrofulaceum with Clarithromycin

:  Cutaneous infection arising from Mycobacterium scrofulaceum, a nontuberculous mycobacteria, has rarely been reported, and most of the reported infections were disseminated forms in patients with AIDS or other immunocompromising illness. We describe an occurrence of localized mycobacterial skin in...

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Bibliographic Details
Published in:Pediatric dermatology 2005-09, Vol.22 (5), p.476-479
Main Authors: Jang, Ho-Sun, Jo, Ju-Hyun, Oh, Chang-Keun, Kim, Moon-Bum, Lee, Jae-Bong, Chang, Chulhun L., Kwon, Yoo-Wook, Kwon, Kyung-Sool
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Bacterial diseases
Biological and medical sciences
Child, Preschool
Clarithromycin - therapeutic use
Female
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Mycobacterium
Mycobacterium Infections, Nontuberculous - complications
Mycobacterium Infections, Nontuberculous - drug therapy
Mycobacterium scrofulaceum
Mycobacterium scrofulaceum - isolation & purification
Skin Diseases, Bacterial - drug therapy
Skin Diseases, Bacterial - microbiology
Tuberculosis and atypical mycobacterial infections
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Summary::  Cutaneous infection arising from Mycobacterium scrofulaceum, a nontuberculous mycobacteria, has rarely been reported, and most of the reported infections were disseminated forms in patients with AIDS or other immunocompromising illness. We describe an occurrence of localized mycobacterial skin infection caused by M. scrofulaceum in a previously healthy child that manifested as a red nodule on the cheek. A biopsy specimen of the lesion demonstrated granulomatous infiltration in the dermis. M. scrofulaceum was isolated from culture of a tissue specimen. Polymerase chain reaction amplified specific fragments for M. scrofulaceum. The patient was treated successfully with clarithromycin as monotherapy for 6 months, leading to complete healing without recurrence during a follow‐up period of 2 years.
ISSN:0736-8046
1525-1470
DOI:10.1111/j.1525-1470.2005.00120.x