Photoinduced antitumour effect of hypericin can be enhanced by fractionated dosing

The in vivo antitumour activity of the natural photosensitizer hypericin was evaluated. C3H/DiSn mice were inoculated with fibrosarcoma G5:1:13 cells. When the tumour reached a volume of 40–80 mm 3 the mice were intraperitoneally injected with hypericin, either in a single dose (5 mg/kg; 1 or 6 h be...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2005-09, Vol.12 (9), p.680-683
Main Authors: Čavarga, I., Brezáni, P., Fedoročko, P., Miškovský, P., Bobrov, N., Longauer, F., Rybárová, S., Mirossay, L., Štubňa, J.
Format: Article
Language:English
Subjects:
Animals
anticarcinogenic activity
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Antiviral agents
Cancer
Cancerotherapy
Care and treatment
Cell Line, Tumor - drug effects
dosage
Drug Administration Schedule
fibrosarcoma
Fibrosarcoma - drug therapy
Hypericin
Hypericum
Injections, Intraperitoneal
irradiation
lasers
Light
Male
Mice
Mice, Inbred Strains
Perylene - administration & dosage
Perylene - analogs & derivatives
Perylene - pharmacology
Perylene - therapeutic use
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - administration & dosage
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
Phytotherapy
Tumour
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Summary:The in vivo antitumour activity of the natural photosensitizer hypericin was evaluated. C3H/DiSn mice were inoculated with fibrosarcoma G5:1:13 cells. When the tumour reached a volume of 40–80 mm 3 the mice were intraperitoneally injected with hypericin, either in a single dose (5 mg/kg; 1 or 6 h before laser irradiation) or two fractionated doses (2.5 mg/kg; 6 and 1 h before irradiation with laser light; 532 nm, 70 mW/cm 2, 168 J/cm 2). All tumours in control groups treated with hypericin alone as well as those irradiated with laser light alone had similar growth rates and none of these tumours regressed spontaneously. Complete remission of tumour in photodynamic therapy (PDT)-treated groups was similar (14–17% single dose vs. 33% fractionated dose), but the fractionated schedule of hypericin dosing was found to be more efficient than the single dose, measured by survival assay ( p < 0.05 ). Our experimental model showed that fractionated administration of hypericin can produce a better therapeutic response than single administration.
ISSN:0944-7113
1618-095X
DOI:10.1016/j.phymed.2004.02.011