Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins

Two novel C16:0 sulfur-linked phosphonolipids (S-lipid and SO 2-lipid) and two ether-linked phosphonolipids (C16:0 DEPN-8 and C16:1 UnDEPN-8) were studied for surface behavior alone and in mixtures with purified bovine lung surfactant proteins (SP)-B and/or SP-C. Synthetic C16:0 phosphonolipids all...

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Bibliographic Details
Published in:Chemistry and physics of lipids 2005-10, Vol.137 (1), p.77-93
Main Authors: Chang, Yusuo, Wang, Zhengdong, Schwan, Adrian L., Wang, Zhongyi, Holm, Bruce A., Baatz, John E., Notter, Robert H.
Format: Article
Language:English
Subjects:
Adsorption
Animals
Cattle
DEPN-8
Ethers - chemistry
Hydrophobic and Hydrophilic Interactions
Lipid analogs
Lung surfactants
Phospholipases A - chemistry
Phospholipids - chemistry
Phosphonolipids
Pulmonary Surfactant-Associated Protein B - chemistry
Pulmonary Surfactant-Associated Protein C - chemistry
Sulfones - chemistry
Surface Tension
Surfactant therapy
Thermodynamics
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Summary:Two novel C16:0 sulfur-linked phosphonolipids (S-lipid and SO 2-lipid) and two ether-linked phosphonolipids (C16:0 DEPN-8 and C16:1 UnDEPN-8) were studied for surface behavior alone and in mixtures with purified bovine lung surfactant proteins (SP)-B and/or SP-C. Synthetic C16:0 phosphonolipids all had improved adsorption and film respreading compared to dipalmitoyl phosphatidylcholine, and SO 2-lipid and DEPN-8 reached maximum surface pressures of 72 mN/m (minimum surface tensions of
ISSN:0009-3084
1873-2941
DOI:10.1016/j.chemphyslip.2005.07.002