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Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins
Two novel C16:0 sulfur-linked phosphonolipids (S-lipid and SO 2-lipid) and two ether-linked phosphonolipids (C16:0 DEPN-8 and C16:1 UnDEPN-8) were studied for surface behavior alone and in mixtures with purified bovine lung surfactant proteins (SP)-B and/or SP-C. Synthetic C16:0 phosphonolipids all...
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| Published in: | Chemistry and physics of lipids 2005-10, Vol.137 (1), p.77-93 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c375t-97527d597601be674bedf0a7b022bf26093a2323cde2b28e662f0aaf9fdce2d73 |
| container_end_page | 93 |
| container_issue | 1 |
| container_start_page | 77 |
| container_title | Chemistry and physics of lipids |
| container_volume | 137 |
| creator | Chang, Yusuo Wang, Zhengdong Schwan, Adrian L. Wang, Zhongyi Holm, Bruce A. Baatz, John E. Notter, Robert H. |
| description | Two novel C16:0 sulfur-linked phosphonolipids (S-lipid and SO
2-lipid) and two ether-linked phosphonolipids (C16:0 DEPN-8 and C16:1 UnDEPN-8) were studied for surface behavior alone and in mixtures with purified bovine lung surfactant proteins (SP)-B and/or SP-C. Synthetic C16:0 phosphonolipids all had improved adsorption and film respreading compared to dipalmitoyl phosphatidylcholine, and SO
2-lipid and DEPN-8 reached maximum surface pressures of 72
mN/m (minimum surface tensions of |
| doi_str_mv | 10.1016/j.chemphyslip.2005.07.002 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68641824</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0009308405001088</els_id><sourcerecordid>68641824</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-97527d597601be674bedf0a7b022bf26093a2323cde2b28e662f0aaf9fdce2d73</originalsourceid><addsrcrecordid>eNqNkE2v1CAUhonReOd-_AWDG3etQFtol2biV3ITF17XhMLBMnZK5UMzi_vfpc4k16ULAic85zw5L0KvKakpofztodYTHNfpFGe31oyQriaiJoQ9Qzvai6ZiQ0ufox0hZKga0rdX6DrGQylJ19GX6IpySoZmoDv0-DUHqzTgNfgVQnIQsbc45tnmUGG1GAxpglDNbvkBBq-Tj-Usvpidifi3S9Nfanv4nPCag7OukNPJlJGTH53Gc16-l5mbKaklbbIEbom36IVVc4S7y32Dvn14_7D_VN1_-fh5_-6-0o3oUjWIjgnTDYITOgIX7QjGEiVGwthoGS-7KNawRhtgI-uBc1a-lR2s0cCMaG7Qm_PcIv6ZISZ5dFHDPKsFfI6S97ylPWsLOJxBHXyMAaxcgzuqcJKUyC17eZD_ZC-37CURsmRfel9dJHk8gnnqvIRdgP0ZgLLqLwdBRu1g0WBcAJ2k8e4_NH8ATn6f6Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68641824</pqid></control><display><type>article</type><title>Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Chang, Yusuo ; Wang, Zhengdong ; Schwan, Adrian L. ; Wang, Zhongyi ; Holm, Bruce A. ; Baatz, John E. ; Notter, Robert H.</creator><creatorcontrib>Chang, Yusuo ; Wang, Zhengdong ; Schwan, Adrian L. ; Wang, Zhongyi ; Holm, Bruce A. ; Baatz, John E. ; Notter, Robert H.</creatorcontrib><description>Two novel C16:0 sulfur-linked phosphonolipids (S-lipid and SO
2-lipid) and two ether-linked phosphonolipids (C16:0 DEPN-8 and C16:1 UnDEPN-8) were studied for surface behavior alone and in mixtures with purified bovine lung surfactant proteins (SP)-B and/or SP-C. Synthetic C16:0 phosphonolipids all had improved adsorption and film respreading compared to dipalmitoyl phosphatidylcholine, and SO
2-lipid and DEPN-8 reached maximum surface pressures of 72
mN/m (minimum surface tensions of <1
mN/m) in compressed films on the Wilhelmy balance (23
°C). Dispersions of DEPN-8 (0.5
mg/ml) and SO
2-lipid (2.5
mg/ml) also reached minimum surface tensions of <1
mN/m on a pulsating bubble surfactometer (37
°C, 20
cycles/min, 50% area compression). Synthetic lung surfactants containing DEPN-8 or SO
2-lipid
+
0.75% SP-B
+
0.75% SP-C had dynamic surface activity on the bubble equal to that of calf lung surfactant extract (CLSE). Surfactants containing DEPN-8 or SO
2-lipid plus 1.5% SP-B also had very high surface activity, but less than when both apoproteins were present together. Adding 10
wt.% of UnDEPN-8 to synthetic lung surfactants did not improve dynamic surface activity. Surfactants containing DEPN-8 or SO
2-lipid plus 0.75% SP-B/0.75% SP-C were chemically and biophysically resistant to phospholipase A
2 (PLA
2), while CLSE was severely inhibited by PLA
2. The high activity and inhibition resistance of synthetic surfactants containing DEPN-8 or SO
2-lipid plus SP-B/SP-C are promising for future applications in treating surfactant dysfunction in inflammatory lung injury.</description><identifier>ISSN: 0009-3084</identifier><identifier>EISSN: 1873-2941</identifier><identifier>DOI: 10.1016/j.chemphyslip.2005.07.002</identifier><identifier>PMID: 16109391</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adsorption ; Animals ; Cattle ; DEPN-8 ; Ethers - chemistry ; Hydrophobic and Hydrophilic Interactions ; Lipid analogs ; Lung surfactants ; Phospholipases A - chemistry ; Phospholipids - chemistry ; Phosphonolipids ; Pulmonary Surfactant-Associated Protein B - chemistry ; Pulmonary Surfactant-Associated Protein C - chemistry ; Sulfones - chemistry ; Surface Tension ; Surfactant therapy ; Thermodynamics</subject><ispartof>Chemistry and physics of lipids, 2005-10, Vol.137 (1), p.77-93</ispartof><rights>2005 Elsevier Ireland Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-97527d597601be674bedf0a7b022bf26093a2323cde2b28e662f0aaf9fdce2d73</citedby><cites>FETCH-LOGICAL-c375t-97527d597601be674bedf0a7b022bf26093a2323cde2b28e662f0aaf9fdce2d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16109391$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Yusuo</creatorcontrib><creatorcontrib>Wang, Zhengdong</creatorcontrib><creatorcontrib>Schwan, Adrian L.</creatorcontrib><creatorcontrib>Wang, Zhongyi</creatorcontrib><creatorcontrib>Holm, Bruce A.</creatorcontrib><creatorcontrib>Baatz, John E.</creatorcontrib><creatorcontrib>Notter, Robert H.</creatorcontrib><title>Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins</title><title>Chemistry and physics of lipids</title><addtitle>Chem Phys Lipids</addtitle><description>Two novel C16:0 sulfur-linked phosphonolipids (S-lipid and SO
2-lipid) and two ether-linked phosphonolipids (C16:0 DEPN-8 and C16:1 UnDEPN-8) were studied for surface behavior alone and in mixtures with purified bovine lung surfactant proteins (SP)-B and/or SP-C. Synthetic C16:0 phosphonolipids all had improved adsorption and film respreading compared to dipalmitoyl phosphatidylcholine, and SO
2-lipid and DEPN-8 reached maximum surface pressures of 72
mN/m (minimum surface tensions of <1
mN/m) in compressed films on the Wilhelmy balance (23
°C). Dispersions of DEPN-8 (0.5
mg/ml) and SO
2-lipid (2.5
mg/ml) also reached minimum surface tensions of <1
mN/m on a pulsating bubble surfactometer (37
°C, 20
cycles/min, 50% area compression). Synthetic lung surfactants containing DEPN-8 or SO
2-lipid
+
0.75% SP-B
+
0.75% SP-C had dynamic surface activity on the bubble equal to that of calf lung surfactant extract (CLSE). Surfactants containing DEPN-8 or SO
2-lipid plus 1.5% SP-B also had very high surface activity, but less than when both apoproteins were present together. Adding 10
wt.% of UnDEPN-8 to synthetic lung surfactants did not improve dynamic surface activity. Surfactants containing DEPN-8 or SO
2-lipid plus 0.75% SP-B/0.75% SP-C were chemically and biophysically resistant to phospholipase A
2 (PLA
2), while CLSE was severely inhibited by PLA
2. The high activity and inhibition resistance of synthetic surfactants containing DEPN-8 or SO
2-lipid plus SP-B/SP-C are promising for future applications in treating surfactant dysfunction in inflammatory lung injury.</description><subject>Adsorption</subject><subject>Animals</subject><subject>Cattle</subject><subject>DEPN-8</subject><subject>Ethers - chemistry</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Lipid analogs</subject><subject>Lung surfactants</subject><subject>Phospholipases A - chemistry</subject><subject>Phospholipids - chemistry</subject><subject>Phosphonolipids</subject><subject>Pulmonary Surfactant-Associated Protein B - chemistry</subject><subject>Pulmonary Surfactant-Associated Protein C - chemistry</subject><subject>Sulfones - chemistry</subject><subject>Surface Tension</subject><subject>Surfactant therapy</subject><subject>Thermodynamics</subject><issn>0009-3084</issn><issn>1873-2941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkE2v1CAUhonReOd-_AWDG3etQFtol2biV3ITF17XhMLBMnZK5UMzi_vfpc4k16ULAic85zw5L0KvKakpofztodYTHNfpFGe31oyQriaiJoQ9Qzvai6ZiQ0ufox0hZKga0rdX6DrGQylJ19GX6IpySoZmoDv0-DUHqzTgNfgVQnIQsbc45tnmUGG1GAxpglDNbvkBBq-Tj-Usvpidifi3S9Nfanv4nPCag7OukNPJlJGTH53Gc16-l5mbKaklbbIEbom36IVVc4S7y32Dvn14_7D_VN1_-fh5_-6-0o3oUjWIjgnTDYITOgIX7QjGEiVGwthoGS-7KNawRhtgI-uBc1a-lR2s0cCMaG7Qm_PcIv6ZISZ5dFHDPKsFfI6S97ylPWsLOJxBHXyMAaxcgzuqcJKUyC17eZD_ZC-37CURsmRfel9dJHk8gnnqvIRdgP0ZgLLqLwdBRu1g0WBcAJ2k8e4_NH8ATn6f6Q</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Chang, Yusuo</creator><creator>Wang, Zhengdong</creator><creator>Schwan, Adrian L.</creator><creator>Wang, Zhongyi</creator><creator>Holm, Bruce A.</creator><creator>Baatz, John E.</creator><creator>Notter, Robert H.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20051001</creationdate><title>Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins</title><author>Chang, Yusuo ; Wang, Zhengdong ; Schwan, Adrian L. ; Wang, Zhongyi ; Holm, Bruce A. ; Baatz, John E. ; Notter, Robert H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-97527d597601be674bedf0a7b022bf26093a2323cde2b28e662f0aaf9fdce2d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adsorption</topic><topic>Animals</topic><topic>Cattle</topic><topic>DEPN-8</topic><topic>Ethers - chemistry</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Lipid analogs</topic><topic>Lung surfactants</topic><topic>Phospholipases A - chemistry</topic><topic>Phospholipids - chemistry</topic><topic>Phosphonolipids</topic><topic>Pulmonary Surfactant-Associated Protein B - chemistry</topic><topic>Pulmonary Surfactant-Associated Protein C - chemistry</topic><topic>Sulfones - chemistry</topic><topic>Surface Tension</topic><topic>Surfactant therapy</topic><topic>Thermodynamics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Yusuo</creatorcontrib><creatorcontrib>Wang, Zhengdong</creatorcontrib><creatorcontrib>Schwan, Adrian L.</creatorcontrib><creatorcontrib>Wang, Zhongyi</creatorcontrib><creatorcontrib>Holm, Bruce A.</creatorcontrib><creatorcontrib>Baatz, John E.</creatorcontrib><creatorcontrib>Notter, Robert H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry and physics of lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Yusuo</au><au>Wang, Zhengdong</au><au>Schwan, Adrian L.</au><au>Wang, Zhongyi</au><au>Holm, Bruce A.</au><au>Baatz, John E.</au><au>Notter, Robert H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins</atitle><jtitle>Chemistry and physics of lipids</jtitle><addtitle>Chem Phys Lipids</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>137</volume><issue>1</issue><spage>77</spage><epage>93</epage><pages>77-93</pages><issn>0009-3084</issn><eissn>1873-2941</eissn><abstract>Two novel C16:0 sulfur-linked phosphonolipids (S-lipid and SO
2-lipid) and two ether-linked phosphonolipids (C16:0 DEPN-8 and C16:1 UnDEPN-8) were studied for surface behavior alone and in mixtures with purified bovine lung surfactant proteins (SP)-B and/or SP-C. Synthetic C16:0 phosphonolipids all had improved adsorption and film respreading compared to dipalmitoyl phosphatidylcholine, and SO
2-lipid and DEPN-8 reached maximum surface pressures of 72
mN/m (minimum surface tensions of <1
mN/m) in compressed films on the Wilhelmy balance (23
°C). Dispersions of DEPN-8 (0.5
mg/ml) and SO
2-lipid (2.5
mg/ml) also reached minimum surface tensions of <1
mN/m on a pulsating bubble surfactometer (37
°C, 20
cycles/min, 50% area compression). Synthetic lung surfactants containing DEPN-8 or SO
2-lipid
+
0.75% SP-B
+
0.75% SP-C had dynamic surface activity on the bubble equal to that of calf lung surfactant extract (CLSE). Surfactants containing DEPN-8 or SO
2-lipid plus 1.5% SP-B also had very high surface activity, but less than when both apoproteins were present together. Adding 10
wt.% of UnDEPN-8 to synthetic lung surfactants did not improve dynamic surface activity. Surfactants containing DEPN-8 or SO
2-lipid plus 0.75% SP-B/0.75% SP-C were chemically and biophysically resistant to phospholipase A
2 (PLA
2), while CLSE was severely inhibited by PLA
2. The high activity and inhibition resistance of synthetic surfactants containing DEPN-8 or SO
2-lipid plus SP-B/SP-C are promising for future applications in treating surfactant dysfunction in inflammatory lung injury.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>16109391</pmid><doi>10.1016/j.chemphyslip.2005.07.002</doi><tpages>17</tpages></addata></record> |
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| ispartof | Chemistry and physics of lipids, 2005-10, Vol.137 (1), p.77-93 |
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| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Adsorption Animals Cattle DEPN-8 Ethers - chemistry Hydrophobic and Hydrophilic Interactions Lipid analogs Lung surfactants Phospholipases A - chemistry Phospholipids - chemistry Phosphonolipids Pulmonary Surfactant-Associated Protein B - chemistry Pulmonary Surfactant-Associated Protein C - chemistry Sulfones - chemistry Surface Tension Surfactant therapy Thermodynamics |
| title | Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins |
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