Preserved autonomic function in amenorrheic athletes

• Published in: Journal of applied physiology (1985) 2006-08, Vol.101 (2), p.590-597
• Main Authors: Wenner, Megan M, Prettyman, Allen V, Maser, Raelene E, Farquhar, William B
• Format: Article
• Language: English
• Subjects: Adult; Amenorrhea - physiopathology; Athletes; Autonomic Nervous System - physiology; Baroreflex - physiology; Biological and medical sciences; Blood Pressure - physiology; Cardiovascular Physiological Phenomena; Cardiovascular system; Contraceptives, Oral - pharmacology; Dizziness - physiopathology; Estradiol - physiology; Female; Fundamental and applied biological sciences. Psychology; Heart Rate - physiology; Hormones; Humans; Menstruation; Physical Fitness - physiology; Progesterone - physiology; Reproductive system; Tilt-Table Test; Vagus Nerve - physiology
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.01477.2005

1 Department of Health, Nutrition, and Exercise Sciences, 2 School of Nursing, and 3 Department of Medical Technology, University of Delaware, Newark, Delaware Submitted 22 November 2005 ; accepted in final form 9 May 2006 Reproductive hormones such as estradiol and progesterone are known to influence autonomic cardiovascular regulation. The purpose of this study was to determine whether amenorrheic athletes (AA) have impaired autonomic cardiovascular regulation compared with eumenorrheic athletes (EA). Thirty-five athletes were tested: 13 AA (19 ± 1 yr), 13 EA (21 ± 1 yr), and 9 EA (23 ± 1 yr) on oral contraceptives (EA-OC). Multiple indexes of autonomic cardiovascular regulation were assessed: respiratory sinus arrhythmia (RSA), cardiovagal baroreflex sensitivity (BRS) via phase IV and phase II of the Valsalva maneuver, a spontaneous index of BRS, and the heart rate and blood pressure responses to orthostatic stress (20-min 60° head-up tilt). RSA was not different among the groups. There were no group differences in the spontaneous index of BRS (AA = 30 ± 6, EA = 24 ± 3, EA-OC = 29 ± 5 ms/mmHg) or in phase II (AA = 8 ± 2, EA = 7 ± 1, EA-OC = 8 ± 1 ms/mmHg) of the Valsalva. There was a difference in BRS during phase IV (AA = 21 ± 3, EA = 15 ± 1, EA-OC = 26 ± 6 ms/mmHg; ANOVA P = 0.04). Tukey's post hoc test indicated that BRS was greater in the EA-OC group compared with the EA group ( P = 0.04). There were no differences in cardiovascular responses to orthostatic stress among the groups. In conclusion, AA do not display signs of impaired autonomic function and orthostatic responses compared with EA or EA-OC during the follicular phase of the menstrual cycle. cardiovagal; baroreflex sensitivity; cardiovascular; estrogen Address for reprint requests and other correspondence: W. B. Farquhar, 541 South College Ave., Fred Rust Arena-Office #143/HPL, Newark, DE 19716 (e-mail: wbf{at}udel.edu )