Persistent Symptomless Human Metapneumovirus Infection in Hematopoietic Stem Cell Transplant Recipients

Sequential nasopharyngeal aspirates from patients without respiratory symptoms undergoing hematopoietic stem cell transplantation (HSCT) were tested for genomic RNA of human metapneumovirus (hMPV). Persistent hMPV infection was documented in most of them and confirmed by virus isolation. hMPV infect...

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Bibliographic Details
Published in:The Journal of infectious diseases 2006-08, Vol.194 (4), p.474-478
Main Authors: Debiaggi, Maurizia, Canducci, Filippo, Sampaolo, Michela, Marinozzi, Maria Chiara, Parea, Maurizio, Terulla, Cristina, Colombo, Anna Amelia, Alessandrino, Emilio Paolo, Bragotti, Letizia Zenone, Arghittu, Milena, Goglio, Antonio, Migliavacca, Roberta, Romero, Egidio, Clementi, Massimo
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Child, Preschool
Female
Fundamental and applied biological sciences. Psychology
Genotypes
Hematologic Neoplasms
Hematopoietic Stem Cell Transplantation
Hematopoietic stem cells
Hospital admissions
Human metapneumovirus
Humans
Immunocompromised Host
Incidence
Infant
Infant, Newborn
Infections
Infectious diseases
Italy - epidemiology
Male
Medical sciences
Metapneumovirus
Metapneumovirus - genetics
Metapneumovirus - isolation & purification
Microbiology
Middle Aged
Nasopharynx - virology
Paramyxoviridae Infections - epidemiology
Paramyxoviridae Infections - virology
Pediatrics
Pneumonia, Viral - epidemiology
Pneumonia, Viral - virology
Prospective Studies
Respiratory diseases
Reverse Transcriptase Polymerase Chain Reaction
RNA
RNA, Viral - analysis
Seasons
Viruses
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Description
Summary:Sequential nasopharyngeal aspirates from patients without respiratory symptoms undergoing hematopoietic stem cell transplantation (HSCT) were tested for genomic RNA of human metapneumovirus (hMPV). Persistent hMPV infection was documented in most of them and confirmed by virus isolation. hMPV infection etiology was also evaluated during the same period in samples from pediatric patients with acute respiratory diseases (ARDs). Sequence analysis of hMPV in HSCT recipients documented infection by hMPV genotype A and strong interhost similarity; this pattern differs from that observed in pediatric patients with ARDs. The data indicate that HSCT recipients may frequently develop symptomless hMPV infection
ISSN:0022-1899
1537-6613
DOI:10.1086/505881