Biological correlates of diffusivity in brain abscess

Restricted diffusion in brain abscess is assumed to be due to a combination of inflammatory cells, necrotic debris, viscosity, and macromolecules present in the pus. We performed diffusion‐weighted imaging (DWI) on 41 patients with proven brain abscesses (36 pyogenic and five tuberculous), and corre...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2005-10, Vol.54 (4), p.878-885
Main Authors: Mishra, Asht M., Gupta, Rakesh K., Saksena, Sona, Prasad, Kashi N., Pandey, Chandra M., Rathore, Divya, Purwar, Ankur, Rathore, Ram K.S., Husain, Nuzhat, Jha, Deepak K., Jaggi, Ramandeep S., Husain, Mazhar
Format: Article
Language:English
Subjects:
Adolescent
Adult
Algorithms
apparent diffusion coefficient
Bacterial Infections - complications
Bacterial Infections - metabolism
Bacterial Infections - pathology
brain abscess
Brain Abscess - etiology
Brain Abscess - metabolism
Brain Abscess - pathology
cell density
Child
Child, Preschool
Diffusion Magnetic Resonance Imaging - methods
diffusion-weighted imaging
Female
Humans
Image Enhancement - methods
Image Interpretation, Computer-Assisted - methods
Infant
Male
Middle Aged
Pattern Recognition, Automated - methods
Reproducibility of Results
restricted diffusion
Sensitivity and Specificity
Severity of Illness Index
Statistics as Topic
Water - metabolism
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Summary:Restricted diffusion in brain abscess is assumed to be due to a combination of inflammatory cells, necrotic debris, viscosity, and macromolecules present in the pus. We performed diffusion‐weighted imaging (DWI) on 41 patients with proven brain abscesses (36 pyogenic and five tuberculous), and correlated the apparent diffusion coefficient (ADC) from the abscess cavity with viable cell density, viscosity, and extracellular‐protein content quantified from the pus. On the basis of the correlation between cell density and ADC in animal tumor models and human tumors in the literature, we assumed that the restricted ADC represents the cellular portion in the abscess cavity. We calculated restricted and unrestricted lesion volumes, and modeled cell density over the restricted area with viable cell density per mm3 obtained from the pus. The mean restricted ADC in the cavity (0.65 ± 0.01 × 10–3 mm2/s) correlated inversely with restricted cell density in both the pyogenic (r = −0.90, P =
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.20645