Pro-inflammatory cytokines in acute coronary syndromes: From bench to bedside

Cytokines are produced in a variety of tissues and regulate the expression of a number of inflammatory molecules, leading to destabilization and finally rupture of vulnerable atheromatic plaques. They also participate in the pathophysiology of acute coronary syndromes (ACS) by direct effects on myoc...

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Bibliographic Details
Published in:Cytokine & growth factor reviews 2006-08, Vol.17 (4), p.225-233
Main Authors: Tousoulis, Dimitris, Antoniades, Charalambos, Koumallos, Nikolaos, Stefanadis, Christodoulos
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Acute Disease
Atherosclerosis - immunology
Coronary Disease - diagnosis
Coronary Disease - drug therapy
Coronary Disease - immunology
Cytokines
Cytokines - antagonists & inhibitors
Cytokines - metabolism
Cytokines - physiology
Humans
Inflammation Mediators - antagonists & inhibitors
Inflammation Mediators - metabolism
Inflammation Mediators - physiology
Myocardial Infarction - diagnosis
Myocardial Infarction - immunology
Plaque rupture
Prognosis
Syndrome
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Summary:Cytokines are produced in a variety of tissues and regulate the expression of a number of inflammatory molecules, leading to destabilization and finally rupture of vulnerable atheromatic plaques. They also participate in the pathophysiology of acute coronary syndromes (ACS) by direct effects on myocardial contractility and apoptosis. At a clinical level, circulating cytokines have a prognostic role since they are useful markers predicting future coronary events in patients with advanced atherosclerosis and in patients after ACS.
ISSN:1359-6101
DOI:10.1016/j.cytogfr.2006.04.003