Between Over- and Undertreatment of Invasive Fungal Disease

Pauw comments on Maertens et al's study on preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection. Maertens et al rightly proposed that a randomized trial of preemptive therapy versus empirical therapy should be done to confirm their findings. However,...

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Bibliographic Details
Published in:Clinical infectious diseases 2005-11, Vol.41 (9), p.1251-1253
Main Author: de Pauw, Ben E.
Format: Article
Language:English
Subjects:
Antifungal Agents - therapeutic use
Bacteria
Diagnostic tests
Fungi
Humans
Infectious diseases
Medical treatment
Mycoses - complications
Mycoses - drug therapy
Mycoses - prevention & control
Neutropenia - complications
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Summary:Pauw comments on Maertens et al's study on preemptive antifungal therapy in neutropenic patients at high risk for invasive fungal infection. Maertens et al rightly proposed that a randomized trial of preemptive therapy versus empirical therapy should be done to confirm their findings. However, it may be inadvisable to attempt such a trial, because the value of the conventional empirical strategy against Aspergillus species remains controversial and would fuel endless discussions about which antifungal drugs should be used.
ISSN:1058-4838
1537-6591
DOI:10.1086/496933