Enantioselective construction of stereogenic quaternary centres via Rh-catalyzed asymmetric addition of alkenylboronic acids to alpha,beta-unsaturated pyridylsulfones

The highly enantioselective construction of all-carbon quaternary stereogenic centres via Rh-catalyzed Chiraphos-mediated conjugate addition of alkenylboronic acids to beta,beta-disubstituted alpha,beta-unsaturated 2-pyridylsulfones is described.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2005-10 (39), p.4961-4963
Main Authors: Mauleón, Pablo, Carretero, Juan C
Format: Article
Language:English
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Description
Summary:The highly enantioselective construction of all-carbon quaternary stereogenic centres via Rh-catalyzed Chiraphos-mediated conjugate addition of alkenylboronic acids to beta,beta-disubstituted alpha,beta-unsaturated 2-pyridylsulfones is described.
ISSN:1359-7345
1364-548X
DOI:10.1039/b508142d