Polymorphisms in Four Genes Related to Triglyceride and HDL-cholesterol Levels in the General Japanese Population in 2000

We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (LIPC), and apolipoprotein...

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Bibliographic Details
Published in:Journal of Atherosclerosis and Thrombosis 2005, Vol.12(5), pp.240-250
Main Authors: Arai, Hidenori, Yamamoto, Akira, Matsuzawa, Yuji, Saito, Yasushi, Yamada, Nobuhiro, Oikawa, Shinichi, Mabuchi, Hiroshi, Teramoto, Tamio, Sasaki, Jun, Nakaya, Noriaki, Itakura, Hiroshige, Ishikawa, Yuichi, Ouchi, Yasuyoshi, Horibe, Hiroshi, Egashira, Tohru, Hattori, Hiroaki, Shirahashi, Nobuo, Kita, Toru
Format: Article
Language:English
Subjects:
Apolipoprotein C-III
Apolipoprotein CIII
Apolipoproteins C - genetics
Asian Continental Ancestry Group - genetics
Carrier Proteins - genetics
Cholesterol ester transfer protein
Cholesterol Ester Transfer Proteins
Cholesterol, HDL - blood
Cholesterol, HDL - genetics
Female
Gene Frequency
Genotype
Glycoproteins - genetics
Humans
Hyperlipidemia
Japan - epidemiology
Lipase - genetics
Lipid Metabolism - genetics
Lipoprotein lipase
Lipoprotein Lipase - genetics
Male
Molecular Epidemiology
Polymorphism
Polymorphism, Single Nucleotide
Triglyceride lipase
Triglycerides - blood
Triglycerides - genetics
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Summary:We studied the association of six common polymorphisms of four genes related to lipid metabolism with serum lipid levels. We selected single-nucleotide polymorphisms (SNPs) in the genes for cholesteryl ester transfer protein (CETP), lipoprotein lipase (LPL), hepatic lipase (LIPC), and apolipoprotein CIII (APOC3), and studied 2267 individuals randomly selected from the participants of Serum Lipid Survey 2000. There was a significant association of CETP polymorphism (D442G, Int14 +1 G → A, and TaqIB), LPL polymorphism (S447X), and LIPC polymorphism (−514 → CT) with HDL-cholesterol levels. We also found a significant association of LPL polymorphism (S447X) and APOC3 polymorphism (SstI) with triglyceride levels. This is the largest database showing the association of common genetic variants in lipid metabolism with serum lipid levels in the general Japanese population. Further study is necessary to elucidate the role of these gene polymorphisms in cardiovascular events.
ISSN:1340-3478
1880-3873
DOI:10.5551/jat.12.240