Asymmetric Alkynylation of Aldehydes Catalyzed by an In(III)/BINOL Complex

Asymmetric alkynylation of both aromatic and aliphatic aldehydes using catalytic amounts of In(III)/BINOL is described. Dual activation of both substrates due to the “bifunctional character” of the indium(III) catalyst enables a broad range of substrate generality with high enantioselectivity (83 to...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2005-10, Vol.127 (40), p.13760-13761
Main Authors: Takita, Ryo, Yakura, Kenichiro, Ohshima, Takashi, Shibasaki, Masakatsu
Format: Article
Language:English
Subjects:
Aldehydes - chemical synthesis
Aldehydes - chemistry
Alkynes - chemistry
Catalysis
Chemistry
Exact sciences and technology
Indium - chemistry
Molecular Structure
Naphthols - chemistry
Organic chemistry
Organometallic Compounds - chemistry
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Summary:Asymmetric alkynylation of both aromatic and aliphatic aldehydes using catalytic amounts of In(III)/BINOL is described. Dual activation of both substrates due to the “bifunctional character” of the indium(III) catalyst enables a broad range of substrate generality with high enantioselectivity (83 to >99% ee).
ISSN:0002-7863
1520-5126
DOI:10.1021/ja053946n