Therapeutic total plasma exchange in a child with neuroblastoma-related anti-Hu syndrome

A 5-year-old boy underwent total plasma exchange to remove anti-neuronal anti-Hu autoantibodies as a complication of neuroblastoma, leading to autonomic bowel dysfunction. Total plasma exchange (TPE) resulted eventually in a reduction of autoantibody levels, but, more importantly, led to improvement...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2005-11, Vol.20 (11), p.1655-1656
Main Authors: van Vuurden, Dannis G, Plötz, Frans B, de Jong, Miranda, Bokenkamp, Arend, van Wijk, Joanna A E
Format: Article
Language:English
Subjects:
Autoantibodies - blood
Child, Preschool
ELAV Proteins - immunology
Humans
Male
Nephrology
Neuroblastoma - immunology
Paraneoplastic syndromes
Paraneoplastic Syndromes, Nervous System - immunology
Paraneoplastic Syndromes, Nervous System - therapy
Plasma Exchange
Spinal Cord Neoplasms - immunology
Tumors
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Summary:A 5-year-old boy underwent total plasma exchange to remove anti-neuronal anti-Hu autoantibodies as a complication of neuroblastoma, leading to autonomic bowel dysfunction. Total plasma exchange (TPE) resulted eventually in a reduction of autoantibody levels, but, more importantly, led to improvement of bowel function. TPE proved to be a safe and effective treatment option in neuroblastoma-related anti-Hu syndrome in a child.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-005-2004-8