CXCL16 Influences the Nature and Specificity of CpG-Induced Immune Activation

Unmethylated CpG motifs are present at high frequency in bacterial DNA. They provide a danger signal to the mammalian immune system that triggers a protective immune response characterized by the production of Th1 and proinflammatory cytokines and chemokines. Although the recognition of CpG DNA by B...

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Bibliographic Details
Published in:Journal of Immunology 2006-08, Vol.177 (3), p.1575-1580
Main Authors: Gursel, Mayda, Gursel, Ihsan, Mostowski, Howard S, Klinman, Dennis M
Format: Article
Language:English
Subjects:
Antibodies, Blocking - metabolism
Antibodies, Blocking - physiology
Binding Sites, Antibody
Cell Line
Cell Membrane - genetics
Cell Membrane - metabolism
Cell Membrane - physiology
Cells, Cultured
Chemokine CXCL16
Chemokines, CXC - biosynthesis
Chemokines, CXC - immunology
Chemokines, CXC - physiology
CpG Islands - immunology
Dendritic Cells - immunology
Dendritic Cells - metabolism
Humans
Intracellular Fluid - immunology
Intracellular Fluid - metabolism
Membrane Proteins - metabolism
Oligodeoxyribonucleotides - antagonists & inhibitors
Oligodeoxyribonucleotides - classification
Oligodeoxyribonucleotides - metabolism
Receptors, Scavenger - biosynthesis
Receptors, Scavenger - immunology
Receptors, Scavenger - physiology
Subcellular Fractions - immunology
Subcellular Fractions - metabolism
Toll-Like Receptor 9 - biosynthesis
Toll-Like Receptor 9 - genetics
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Summary:Unmethylated CpG motifs are present at high frequency in bacterial DNA. They provide a danger signal to the mammalian immune system that triggers a protective immune response characterized by the production of Th1 and proinflammatory cytokines and chemokines. Although the recognition of CpG DNA by B cells and plasmacytoid dendritic cells is mediated by TLR 9, these cell types differ in their ability to bind and respond to structurally distinct classes of CpG oligonucleotides. This work establishes that CXCL16, a membrane-bound scavenger receptor, influences the uptake, subcellular localization, and cytokine profile induced by D oligonucleotides. This is the first example of a surface receptor modifying the cellular specificity and nature of the immune response mediated by an intracellular TLR.
ISSN:0022-1767
1550-6606
1365-2567
DOI:10.4049/jimmunol.177.3.1575