Potential possibilities of using phage typing in elimination of multidrug resistant staphylococci

Coagulase-negative staphylococci (CoNS) have become the most often isolated bacteria from blood culture, spinal fluid and respiratory tracts of neonates. These nosocomial strains are often resistant to oxacillin and other antibiotics (macrolides, aminoglycosides and fluorochinolones). 50 multidrug r...

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Bibliographic Details
Published in:Polish journal of microbiology 2005, Vol.54 (1), p.63-67
Main Authors: Drulis-Kawa, Zuzanna, Weber-Dabrowska, Beata, Lusiak-Szelachowska, Marzanna, Doroszkiewicz, Włodzimierz
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Bacteremia - microbiology
Bacteriophage Typing
Coagulase - metabolism
Drug Resistance, Multiple, Bacterial
Humans
Infant, Newborn
Intensive Care Units, Neonatal
Microbial Sensitivity Tests
Multidrug resistance
Phage typing
Phages
Poland
Staphylococcal Infections - microbiology
Staphylococcus - classification
Staphylococcus - drug effects
Staphylococcus - enzymology
Staphylococcus - virology
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Summary:Coagulase-negative staphylococci (CoNS) have become the most often isolated bacteria from blood culture, spinal fluid and respiratory tracts of neonates. These nosocomial strains are often resistant to oxacillin and other antibiotics (macrolides, aminoglycosides and fluorochinolones). 50 multidrug resistant CoNS strains isolated from bloodstream neonatal infections were tested for sensitivity to 23 lytic staphylococcus bacteriophages. No lytic patterns for 19 of the phages were observed. Phages P4, A3R and 676/Z were active against 46%, 54% and 56% of the strains, respectively. In general, 60% of CoNS isolates were susceptible to one or more of the staphylococcus bacteriophages.
ISSN:1733-1331
2544-4646