Histiocytosis and bone: experience from one major Sydney teaching hospital

Langerhans cell histiocytosis (LCH) has diverse presentations which can bring it before all physicians regardless of specialty. A retrospective audit was undertaken at Westmead Hospital, Sydney, Australia, to ascertain the incidence, epidemiology and clinical features of patients with LCH over a 10‐...

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Bibliographic Details
Published in:Internal medicine journal 2005-10, Vol.35 (10), p.622-625
Main Authors: Geevasinga, N., Jeremy, R., Crombie, C. M., Manolios, N.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
bone
Bone Diseases - epidemiology
Bone Diseases - etiology
Bone Diseases - pathology
eosinophilic granuloma
Female
General aspects
Hand-Schuller-Christian disease
Hematologic and hematopoietic diseases
histiocytosis
Histiocytosis, Langerhans-Cell - complications
Histiocytosis, Langerhans-Cell - epidemiology
Histiocytosis, Langerhans-Cell - pathology
Hospitals, Teaching - statistics & numerical data
Humans
Incidence
Langerhans cell
Letterer-Siwe disease
Male
Medical sciences
New South Wales - epidemiology
Other diseases. Hematologic involvement in other diseases
Prevalence
Retrospective Studies
Risk Factors
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Summary:Langerhans cell histiocytosis (LCH) has diverse presentations which can bring it before all physicians regardless of specialty. A retrospective audit was undertaken at Westmead Hospital, Sydney, Australia, to ascertain the incidence, epidemiology and clinical features of patients with LCH over a 10‐year period (1994–2004). A total of 12 patients was identified (six male, six female). Eleven patients had involvement of the skeletal system, three of the patients had pulmonary LCH and only one patient presented with soft tissue involvement (nose and antrum). Three patients had diabetes insipidus. Our results are consistent with that noted in the published literature and confirm the low incidence, diverse nature of presentation and the differing treatment strategies available for this rare and yet interesting condition. (Intern Med J 2005; 35: 622–625)
ISSN:1444-0903
1445-5994
DOI:10.1111/j.1445-5994.2005.00907.x