Variability of vascularity in nasal mucosa as demonstrated by CD34 immunohistochemistry

Keypoints • Regional anatomical variations in the nasal vasculature have not been studied histologically. • Immunohistochemistry performed using marker for CD34 antigen on vascular endothelium biopsied from 5 sites on the lateral nasal wall and compared with one septal biopsy. • No significant regio...

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Bibliographic Details
Published in:Clinical otolaryngology 2005-08, Vol.30 (4), p.373-375
Main Authors: Philpott, C.M., Wild, D., Guzail, M., Murty, G.E.
Format: Article
Language:English
Subjects:
Analysis of Variance
Antigens, CD34 - analysis
Antigens, CD34 - immunology
Biopsy, Fine-Needle
Humans
Immunohistochemistry
Microcirculation - anatomy & histology
Nasal Mucosa - anatomy & histology
Nasal Mucosa - blood supply
Nasal Septum - blood supply
Reproducibility of Results
Turbinates - blood supply
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Summary:Keypoints • Regional anatomical variations in the nasal vasculature have not been studied histologically. • Immunohistochemistry performed using marker for CD34 antigen on vascular endothelium biopsied from 5 sites on the lateral nasal wall and compared with one septal biopsy. • No significant regional variations in microvascular architecture over the lateral wall of the nose were found. • Lateral wall measurements were significantly different to the septal measurements (P = 0.0003, 0.01). • Suggests biopsies can be taken from any site on the lateral wall and give a representative sampling of the vascularity for research purposes.
ISSN:1749-4478
1749-4486
DOI:10.1111/j.1365-2273.2005.00985.x