Pyridostigmine in autonomic failure: can we treat postural hypotension and bladder dysfunction with one drug?

In a 66-year-old man with autonomic failure, pyridostigmine (180 mg/day orally) improved both postural hypotension and underactive detrusor bladder dysfunction. Acetylcholinesterase inhibition may be useful in the management of orthostatic hypotension and bladder dysfunction in autonomic failure pat...

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Bibliographic Details
Published in:Clinical autonomic research 2006-08, Vol.16 (4), p.296-298
Main Authors: Yamamoto, Tatsuya, Sakakibara, Ryuji, Yamanaka, Yoshitaka, Uchiyama, Tomoyuki, Asahina, Masato, Liu, Zhi, Ito, Takashi, Koyama, Yu, Awa, Yusuke, Yamamoto, Kaori, Kinou, Mika, Hattori, Takamichi
Format: Article
Language:English
Subjects:
Acetylcholinesterase
Aged
Autonomic Nervous System Diseases - complications
Autonomic Nervous System Diseases - drug therapy
Bladder
Cholinesterase Inhibitors - therapeutic use
Dysautonomia
Humans
Hypotension
Hypotension, Orthostatic - drug therapy
Hypotension, Orthostatic - etiology
Male
Orthostatic hypotension
Posture
Pyridostigmine
Pyridostigmine Bromide - therapeutic use
Urinary Bladder Diseases - drug therapy
Urinary Bladder Diseases - etiology
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Summary:In a 66-year-old man with autonomic failure, pyridostigmine (180 mg/day orally) improved both postural hypotension and underactive detrusor bladder dysfunction. Acetylcholinesterase inhibition may be useful in the management of orthostatic hypotension and bladder dysfunction in autonomic failure patients.
ISSN:0959-9851
1619-1560
DOI:10.1007/s10286-006-0358-z