Immunological activities are modulated by enteral administration of an elemental diet in mice

Elemental diets (EDs) have been used successfully in treatment of some intestinal inflammatory diseases; however, the mechanism that mediates their effects is still unclear. In this study we evaluated the immunological effect of enteral administration of an ED in mice. C57BL/6 mice were fed an ED (E...

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Bibliographic Details
Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2006-08, Vol.25 (4), p.643-652
Main Authors: Menezes, Juscilene S., Andrade, Mariléia C., Senra, Beatriz, Rodrigues, Virlânia S., Vaz, Nelson M., Faria, Ana Maria C.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Elemental diet
Enteral Nutrition
Enzyme-Linked Immunosorbent Assay - methods
Flow Cytometry - veterinary
Food, Formulated
GALT
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Immunohistochemistry - methods
Immunoregulation
Inflammatory bowel diseases
Intestinal Mucosa - cytology
Intestinal Mucosa - immunology
Intestine, Small - cytology
Intestine, Small - immunology
Lymphocytes - immunology
Lymphoid Tissue - cytology
Lymphoid Tissue - growth & development
Lymphoid Tissue - immunology
Medical sciences
Metabolic diseases
Mice
Mice, Inbred C57BL
Mucosa
Protein
Spleen - cytology
Spleen - immunology
Weaning
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Summary:Elemental diets (EDs) have been used successfully in treatment of some intestinal inflammatory diseases; however, the mechanism that mediates their effects is still unclear. In this study we evaluated the immunological effect of enteral administration of an ED in mice. C57BL/6 mice were fed an ED (El-Diet) from weaning up to adulthood and immunological parameters were analyzed. El-Diet-fed mice presented an underdeveloped gut-associated-lymphoid tissue with lower numbers of TCR αβ+IELs and lamina propria cells and low levels of secretory IgA when compared to chow-fed mice. They showed a systemic decrease in the production of IgG and IgA as well as a skewing towards a Th2 profile of cytokine production upon in vitro stimulation with an increase in IL-4 and a reduction in IFN- γ and IL-6 secretion. Our study demonstrated the role of EDs in modulating immunological activities in mice and proposes a rational for their successful use in treatment of some intestinal inflammatory diseases.
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2006.01.005