Relation of Microalbuminuria and Coronary Artery Disease in Patients With and Without Diabetes Mellitus

• Published in: The American journal of cardiology 2006-08, Vol.98 (3), p.279-281
• Main Authors: Sukhija, Rishi, Aronow, Wilbert S., Kakar, Priyanka, Garza, Luis, Sachdeva, Rajesh, Sinha, Anjan, Mehta, Jawahar L.
• Format: Article
• Language: English
• Subjects: Aged; Albuminuria - complications; Albuminuria - urine; Biological and medical sciences; Cardiology. Vascular system; Cardiovascular disease; Comparative studies; Coronary Angiography; Coronary Disease - diagnostic imaging; Coronary Disease - epidemiology; Coronary Disease - etiology; Coronary heart disease; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - urine; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Follow-Up Studies; Heart; Humans; Male; Medical sciences; Nephrology. Urinary tract diseases; Prevalence; Proteins; Retrospective Studies; Risk Factors; Severity of Illness Index; Survival Rate; Urinary system involvement in other diseases. Miscellaneous; Urinary tract. Prostate gland
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2006.01.098

Microalbuminuria (MA) is a well-known risk factor for coronary artery disease (CAD) in diabetics and nondiabetics. It is associated with higher cardiovascular mortality, especially in diabetics. However, there are few data linking angiographic severity of CAD to microalbuminuria. We examined coronary angiograms for extent of severe CAD (luminal narrowing ≥50%) in patients with type 2 diabetes mellitus (DM) and MA (DM +MA +, n = 101), patients with DM and without MA (DM +MA −, n = 101), patients without DM and with MA (DM −MA +, n = 64), and patients without DM and MA (DM −MA −, n = 64). We also evaluated fasting glucose levels in all patients and glycosylated hemoglobin in diabetics. Patients’ mean age in the DM +MA +, DM +MA −, DM −MA +, and DM −MA − groups was similar. Gender distribution across the 4 groups was also not significantly different. There were no significant differences in the prevalence of hypertension, hypercholesterolemia, and current smoking across the 4 groups. The presence of 2- or 3-vessel CAD showed a linear increase from group DM −MA − to group DM +MA + (p