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Relation of Microalbuminuria and Coronary Artery Disease in Patients With and Without Diabetes Mellitus
Microalbuminuria (MA) is a well-known risk factor for coronary artery disease (CAD) in diabetics and nondiabetics. It is associated with higher cardiovascular mortality, especially in diabetics. However, there are few data linking angiographic severity of CAD to microalbuminuria. We examined coronar...
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| Published in: | The American journal of cardiology 2006-08, Vol.98 (3), p.279-281 |
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| container_end_page | 281 |
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| container_start_page | 279 |
| container_title | The American journal of cardiology |
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| creator | Sukhija, Rishi Aronow, Wilbert S. Kakar, Priyanka Garza, Luis Sachdeva, Rajesh Sinha, Anjan Mehta, Jawahar L. |
| description | Microalbuminuria (MA) is a well-known risk factor for coronary artery disease (CAD) in diabetics and nondiabetics. It is associated with higher cardiovascular mortality, especially in diabetics. However, there are few data linking angiographic severity of CAD to microalbuminuria. We examined coronary angiograms for extent of severe CAD (luminal narrowing ≥50%) in patients with type 2 diabetes mellitus (DM) and MA (DM
+MA
+, n = 101), patients with DM and without MA (DM
+MA
−, n = 101), patients without DM and with MA (DM
−MA
+, n = 64), and patients without DM and MA (DM
−MA
−, n = 64). We also evaluated fasting glucose levels in all patients and glycosylated hemoglobin in diabetics. Patients’ mean age in the DM
+MA
+, DM
+MA
−, DM
−MA
+, and DM
−MA
− groups was similar. Gender distribution across the 4 groups was also not significantly different. There were no significant differences in the prevalence of hypertension, hypercholesterolemia, and current smoking across the 4 groups. The presence of 2- or 3-vessel CAD showed a linear increase from group DM
−MA
− to group DM
+MA
+ (p |
| doi_str_mv | 10.1016/j.amjcard.2006.01.098 |
| format | article |
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+MA
+, n = 101), patients with DM and without MA (DM
+MA
−, n = 101), patients without DM and with MA (DM
−MA
+, n = 64), and patients without DM and MA (DM
−MA
−, n = 64). We also evaluated fasting glucose levels in all patients and glycosylated hemoglobin in diabetics. Patients’ mean age in the DM
+MA
+, DM
+MA
−, DM
−MA
+, and DM
−MA
− groups was similar. Gender distribution across the 4 groups was also not significantly different. There were no significant differences in the prevalence of hypertension, hypercholesterolemia, and current smoking across the 4 groups. The presence of 2- or 3-vessel CAD showed a linear increase from group DM
−MA
− to group DM
+MA
+ (p <0.001). Diabetics with MA had higher fasting glucose and glycosylated hemoglobin levels than diabetics without MA (p <0.001). Thus, patients with MA have more severe angiographic CAD than those without MA. This relation is independent of other risk factors and is particularly evident in patients with DM.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2006.01.098</identifier><identifier>PMID: 16860009</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Albuminuria - complications ; Albuminuria - urine ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular disease ; Comparative studies ; Coronary Angiography ; Coronary Disease - diagnostic imaging ; Coronary Disease - epidemiology ; Coronary Disease - etiology ; Coronary heart disease ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - urine ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Follow-Up Studies ; Heart ; Humans ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Prevalence ; Proteins ; Retrospective Studies ; Risk Factors ; Severity of Illness Index ; Survival Rate ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland</subject><ispartof>The American journal of cardiology, 2006-08, Vol.98 (3), p.279-281</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Aug 1, 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-9a266c65f845ec63d47af1f8df2ad2b02eed81c983b62c833c2a1262e1a8a7703</citedby><cites>FETCH-LOGICAL-c467t-9a266c65f845ec63d47af1f8df2ad2b02eed81c983b62c833c2a1262e1a8a7703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18012695$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16860009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sukhija, Rishi</creatorcontrib><creatorcontrib>Aronow, Wilbert S.</creatorcontrib><creatorcontrib>Kakar, Priyanka</creatorcontrib><creatorcontrib>Garza, Luis</creatorcontrib><creatorcontrib>Sachdeva, Rajesh</creatorcontrib><creatorcontrib>Sinha, Anjan</creatorcontrib><creatorcontrib>Mehta, Jawahar L.</creatorcontrib><title>Relation of Microalbuminuria and Coronary Artery Disease in Patients With and Without Diabetes Mellitus</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>Microalbuminuria (MA) is a well-known risk factor for coronary artery disease (CAD) in diabetics and nondiabetics. It is associated with higher cardiovascular mortality, especially in diabetics. However, there are few data linking angiographic severity of CAD to microalbuminuria. We examined coronary angiograms for extent of severe CAD (luminal narrowing ≥50%) in patients with type 2 diabetes mellitus (DM) and MA (DM
+MA
+, n = 101), patients with DM and without MA (DM
+MA
−, n = 101), patients without DM and with MA (DM
−MA
+, n = 64), and patients without DM and MA (DM
−MA
−, n = 64). We also evaluated fasting glucose levels in all patients and glycosylated hemoglobin in diabetics. Patients’ mean age in the DM
+MA
+, DM
+MA
−, DM
−MA
+, and DM
−MA
− groups was similar. Gender distribution across the 4 groups was also not significantly different. There were no significant differences in the prevalence of hypertension, hypercholesterolemia, and current smoking across the 4 groups. The presence of 2- or 3-vessel CAD showed a linear increase from group DM
−MA
− to group DM
+MA
+ (p <0.001). Diabetics with MA had higher fasting glucose and glycosylated hemoglobin levels than diabetics without MA (p <0.001). Thus, patients with MA have more severe angiographic CAD than those without MA. This relation is independent of other risk factors and is particularly evident in patients with DM.</description><subject>Aged</subject><subject>Albuminuria - complications</subject><subject>Albuminuria - urine</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Comparative studies</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary Disease - etiology</subject><subject>Coronary heart disease</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - urine</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Prevalence</subject><subject>Proteins</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Survival Rate</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkVGL1TAQhYMo7t3Vn6AUQd9ak_Q2TZ5kuboq7KKI4mOYplNNaZvdJBX89871FhZ88Wlm4DvDzDmMPRO8Elyo12MF8-gg9pXkXFVcVNzoB2wndGtKYUT9kO0457I0Ym_O2HlKI41CNOoxOxNKK5rMjv34ghNkH5YiDMWNdzHA1K2zX9booYClLw4hhgXi7-IyZqTy1ieEhIVfis-kxCWn4rvPP__CxyasmSDoMGMqbnCafF7TE_ZogCnh061esG9X774ePpTXn95_PFxel26v2lwakEo51Qx636BTdb9vYRCD7gcJvey4ROy1cEbXnZJO17WTIKSSKEBD2_L6gr067b2N4W7FlO3sk6MjYMGwJkuPq9YIQ-CLf8AxrHGh26ysed1KbVqCmhNEvqQUcbC30c9khhXcHmOwo91isMcYLBeWYiDd82352s3Y36s23wl4uQGQHExDhMX5dM9pTl-Zhrg3Jw7Js18eo02OLHfY-4gu2z74_5zyB38QqK4</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Sukhija, Rishi</creator><creator>Aronow, Wilbert S.</creator><creator>Kakar, Priyanka</creator><creator>Garza, Luis</creator><creator>Sachdeva, Rajesh</creator><creator>Sinha, Anjan</creator><creator>Mehta, Jawahar L.</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Relation of Microalbuminuria and Coronary Artery Disease in Patients With and Without Diabetes Mellitus</title><author>Sukhija, Rishi ; Aronow, Wilbert S. ; Kakar, Priyanka ; Garza, Luis ; Sachdeva, Rajesh ; Sinha, Anjan ; Mehta, Jawahar L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-9a266c65f845ec63d47af1f8df2ad2b02eed81c983b62c833c2a1262e1a8a7703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Albuminuria - complications</topic><topic>Albuminuria - urine</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Comparative studies</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary Disease - etiology</topic><topic>Coronary heart disease</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - urine</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Prevalence</topic><topic>Proteins</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Survival Rate</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sukhija, Rishi</creatorcontrib><creatorcontrib>Aronow, Wilbert S.</creatorcontrib><creatorcontrib>Kakar, Priyanka</creatorcontrib><creatorcontrib>Garza, Luis</creatorcontrib><creatorcontrib>Sachdeva, Rajesh</creatorcontrib><creatorcontrib>Sinha, Anjan</creatorcontrib><creatorcontrib>Mehta, Jawahar L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sukhija, Rishi</au><au>Aronow, Wilbert S.</au><au>Kakar, Priyanka</au><au>Garza, Luis</au><au>Sachdeva, Rajesh</au><au>Sinha, Anjan</au><au>Mehta, Jawahar L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relation of Microalbuminuria and Coronary Artery Disease in Patients With and Without Diabetes Mellitus</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>98</volume><issue>3</issue><spage>279</spage><epage>281</epage><pages>279-281</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>Microalbuminuria (MA) is a well-known risk factor for coronary artery disease (CAD) in diabetics and nondiabetics. It is associated with higher cardiovascular mortality, especially in diabetics. However, there are few data linking angiographic severity of CAD to microalbuminuria. We examined coronary angiograms for extent of severe CAD (luminal narrowing ≥50%) in patients with type 2 diabetes mellitus (DM) and MA (DM
+MA
+, n = 101), patients with DM and without MA (DM
+MA
−, n = 101), patients without DM and with MA (DM
−MA
+, n = 64), and patients without DM and MA (DM
−MA
−, n = 64). We also evaluated fasting glucose levels in all patients and glycosylated hemoglobin in diabetics. Patients’ mean age in the DM
+MA
+, DM
+MA
−, DM
−MA
+, and DM
−MA
− groups was similar. Gender distribution across the 4 groups was also not significantly different. There were no significant differences in the prevalence of hypertension, hypercholesterolemia, and current smoking across the 4 groups. The presence of 2- or 3-vessel CAD showed a linear increase from group DM
−MA
− to group DM
+MA
+ (p <0.001). Diabetics with MA had higher fasting glucose and glycosylated hemoglobin levels than diabetics without MA (p <0.001). Thus, patients with MA have more severe angiographic CAD than those without MA. This relation is independent of other risk factors and is particularly evident in patients with DM.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16860009</pmid><doi>10.1016/j.amjcard.2006.01.098</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9149 |
| ispartof | The American journal of cardiology, 2006-08, Vol.98 (3), p.279-281 |
| issn | 0002-9149 1879-1913 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Aged Albuminuria - complications Albuminuria - urine Biological and medical sciences Cardiology. Vascular system Cardiovascular disease Comparative studies Coronary Angiography Coronary Disease - diagnostic imaging Coronary Disease - epidemiology Coronary Disease - etiology Coronary heart disease Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - urine Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Follow-Up Studies Heart Humans Male Medical sciences Nephrology. Urinary tract diseases Prevalence Proteins Retrospective Studies Risk Factors Severity of Illness Index Survival Rate Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland |
| title | Relation of Microalbuminuria and Coronary Artery Disease in Patients With and Without Diabetes Mellitus |
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