Central compensation at short muscle range is differentially affected in cortical versus subcortical strokes

The active force generated by a single muscle fiber is greatest in midrange. In healthy subjects, the reduced muscle force at short muscle length is partially compensated by modified patterns of muscle activation, probably central in origin. These patterns are presumed to be deficient after stroke....

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Bibliographic Details
Published in:Stroke (1970) 2006-08, Vol.37 (8), p.2076-2080
Main Authors: RENNER, Caroline I. E, WOLDAG, Hartwig, HUMMELSHEIM, Horst
Format: Article
Language:English
Subjects:
Adaptation, Physiological
Adult
Aged
Arm
Biological and medical sciences
Case-Control Studies
Evoked Potentials, Motor
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Male
Medical sciences
Middle Aged
Muscle, Skeletal - physiopathology
Nervous system (semeiology, syndromes)
Neurology
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
Pyramidal Tracts - physiopathology
Serotoninergic system
Stroke - classification
Stroke - physiopathology
Transcranial Magnetic Stimulation
Vascular diseases and vascular malformations of the nervous system
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Summary:The active force generated by a single muscle fiber is greatest in midrange. In healthy subjects, the reduced muscle force at short muscle length is partially compensated by modified patterns of muscle activation, probably central in origin. These patterns are presumed to be deficient after stroke. We examined the excitability muscle-length relation in stroke patients and healthy controls and hypothesized about its alteration in stroke patients. Corticospinal excitability was assessed in 31 stroke patients (19 subcortical, 12 cortical) and 19 healthy volunteers by transcranial magnetic stimulation. We recorded the motor evoked potentials (MEPs) simultaneously from the biceps brachii and the triceps brachii muscles at 0 degrees, 20 degrees, 40 degrees, 60 degrees, 80 degrees, 100 degrees, and 120 degrees degrees of elbow flexion (0 degrees being full elbow extension). Normal subjects revealed a significant increase in MEP amplitudes at shortened muscle lengths for both the flexor and extensor muscles (P
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000229876.29608.85