Malignant myoepithelioma arising from recurrent pleomorphic adenoma of the soft palate

Malignant myoepithelioma is a rare salivary gland neoplasm that can arise either de novo or within a pre-existing pleomorphic adenoma. We report a case of malignant myoepithelioma arising from a pleomorphic adenoma of the soft palate. A 70-year-old woman presented in our department with a very large...

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Bibliographic Details
Published in:Auris, nasus, larynx nasus, larynx, 2005-12, Vol.32 (4), p.435-437
Main Authors: Karatzanis, Alexandros D., Drivas, Emmanouil I., Giannikaki, Elpida S., Lachanas, Vasilios A., Hatziioannou, John K., Velegrakis, George A.
Format: Article
Language:English
Subjects:
Adenoma, Pleomorphic - pathology
Adenoma, Pleomorphic - surgery
Aged
Female
Humans
Magnetic Resonance Imaging
Malignant myoepithelioma
Minor salivary gland
Myoepithelioma - pathology
Myoepithelioma - surgery
Neoplasm Invasiveness
Neoplasm Staging
Palate, Soft - pathology
Palate, Soft - surgery
Pharyngeal Neoplasms - pathology
Pharyngeal Neoplasms - surgery
Pleomorphic adenoma
Salivary Gland Neoplasms - pathology
Salivary Gland Neoplasms - surgery
Soft palate
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Summary:Malignant myoepithelioma is a rare salivary gland neoplasm that can arise either de novo or within a pre-existing pleomorphic adenoma. We report a case of malignant myoepithelioma arising from a pleomorphic adenoma of the soft palate. A 70-year-old woman presented in our department with a very large tumor of the soft palate. The patient had a history of a pleomorphic adenoma at the same location that was surgically removed 2 years ago. A second operation, with intraoral excision of the tumor was performed. Histological examination of the recurrence revealed a malignant spindle cell neoplasm with an infiltrative growth pattern and a high mitotic rate. Immunohistochemical investigation confirmed the diagnosis of a low-grade carcinoma of myoepithelial origin with free surgical margins. The patient remains free of disease for more than twelve months after the end of treatment.
ISSN:0385-8146
1879-1476
DOI:10.1016/j.anl.2005.04.001