Murine microglia are effective phagocytes for Borrelia burgdorferi

Lyme disease is a multi-systemic infection that causes diverse neurologic dysfunction collectively known as neuroborreliosis. In the murine model of Lyme disease, Borrelia burgdorferi are seldom found in the nervous system indicating that the spirochetes are rapidly cleared from the brain and periph...

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Bibliographic Details
Published in:Journal of neuroimmunology 2005-11, Vol.168 (1), p.183-187
Main Authors: Kuhlow, Christopher J., Garcia-Monco, Juan C., Coleman, James L., Benach, Jorge L.
Format: Article
Language:English
Subjects:
Animals
Antigens, Surface - metabolism
B. burgdorferi
Bacterial Outer Membrane Proteins - metabolism
Bacterial Vaccines
Borrelia burgdorferi
Cathepsin L
Cathepsins - metabolism
Cell Survival
Cysteine Endopeptidases - metabolism
Fluorescent Antibody Technique - methods
Lipoproteins - metabolism
Lyme Disease - microbiology
Lyme Disease - pathology
Lyme neuroborreliosis
Membrane Proteins - metabolism
Mice
Microglia
Microglia - physiology
Phagocytes - physiology
Phagocytosis
Time Factors
Vesicular Transport Proteins
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Summary:Lyme disease is a multi-systemic infection that causes diverse neurologic dysfunction collectively known as neuroborreliosis. In the murine model of Lyme disease, Borrelia burgdorferi are seldom found in the nervous system indicating that the spirochetes are rapidly cleared from the brain and peripheral nerves. In the present study, we examined the interaction between microglia and B. burgdorferi. Murine microglia are efficient phagocytes and are capable of ingesting and killing spirochetes with or without opsonization.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2005.06.030