Outcome of Renal Transplantation in Children With Low Urinary Tract Abnormality

• Published in: Transplantation proceedings 2005-09, Vol.37 (7), p.3071-3074
• Main Authors: Otukesh, H., Sharifian, M., Simfroosh, N., Basiri, A., Hoseini, R., Sedigh, N., Golnari, P., Rezai, M., Fereshtenejad, M.
• Format: Article
• Language: English
• Subjects: Acute Disease; Biological and medical sciences; Child; Chronic Disease; Creatinine - blood; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft Rejection - epidemiology; Graft Survival; Humans; Immunosuppressive Agents - therapeutic use; Kidney Transplantation - immunology; Kidney Transplantation - physiology; Male; Medical sciences; Retrospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the urinary system; Tissue, organ and graft immunology; Treatment Outcome; Urinary Tract - abnormalities
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2005.08.026

Patients with end-stage renal disease and lower urinary tract abnormality are often considered high risk for renal transplantation. To examine the degree of risk, we studied patients who received renal transplants between 1985 and 2003. Forty eight patients had congenital lower urinary tract anomalies and 168 patients comprised a control group without these anomalies. Mean age and distribution of sex were not significantly different between the case and the control group. Among patients with anomalies, 8% had delayed graft function; 75%, acute rejection; and 39.5%, chronic rejection. Among the controls 2.3% had delayed graft function; 59%, acute rejection; and 35%, chronic rejection. None of these differences was significant. Mean survival time was 6 years in affected patients and 7.3 years in the control group ( P = .7). Among patients with anomalies the rate of graft survival in the first year after transplantation was 90%; and those in the third, fifth, and seventh years, 76%, 65%, and 40%, respectively. For the controls, the graft survivals were 88% at 1 year; 73% at 3 years; 70% at 5 years; and 49% at 7 years after transplantation. This study showed that a history of lower urinary tract anomalies had no effect on graft function. Graft survival was not different among these patients compared with patients free of these anomalies.