Cryo-electron Microscopy of the Giant Mimivirus

Mimivirus is the largest known virus. Using cryo-electron microscopy, the virus was shown to be icosahedral, covered by long fibers, and appears to have at least two lipid membranes within its protein capsid. A unique vertex, presumably for attachment and infection of the host, can be seen for parti...

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Bibliographic Details
Published in:Journal of molecular biology 2005-10, Vol.353 (3), p.493-496
Main Authors: Xiao, Chuan, Chipman, Paul R., Battisti, Anthony J., Bowman, Valorie D., Renesto, Patricia, Raoult, Didier, Rossmann, Michael G.
Format: Article
Language:English
Subjects:
Capsid - ultrastructure
Cryoelectron Microscopy - methods
cryoEM
Membrane Lipids - chemistry
Mimivirus
nucleocytoplasmic dsDNA
structure
unique vertex
Viruses - ultrastructure
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Summary:Mimivirus is the largest known virus. Using cryo-electron microscopy, the virus was shown to be icosahedral, covered by long fibers, and appears to have at least two lipid membranes within its protein capsid. A unique vertex, presumably for attachment and infection of the host, can be seen for particles that have a suitable orientation on the micrographs.
ISSN:0022-2836
1089-8638
DOI:10.1016/j.jmb.2005.08.060