Effects of probiotic bacteria in dogs with food responsive diarrhoea treated with an elimination diet

Summary We evaluated whether a probiotic supplementation in dogs with food responsive diarrhoea (FRD) has beneficial effects on intestinal cytokine patterns and on microbiota. Twenty‐one client‐owned dogs with FRD were presented for clinically needed duodeno‐ and colonoscopy and were enrolled in a p...

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Published in:Journal of animal physiology and animal nutrition 2006-08, Vol.90 (7-8), p.269-277
Main Authors: Sauter, S. N., Benyacoub, J., Allenspach, K., Gaschen, F., Ontsouka, E., Reuteler, G., Cavadini, C., Knorr, R., Blum, J. W.
Format: Article
Language:English
Subjects:
Animal Feed
Animal Nutritional Physiological Phenomena
Animals
Bifidobacterium - growth & development
Colon - immunology
Colon - microbiology
Colon - pathology
Cytokines - biosynthesis
Diarrhea - drug therapy
Diarrhea - microbiology
Diarrhea - pathology
Diarrhea - veterinary
Dietary Supplements
Dog Diseases - drug therapy
Dog Diseases - microbiology
Dog Diseases - pathology
Dogs
Double-Blind Method
Duodenum - immunology
Duodenum - microbiology
Duodenum - pathology
Enterobacteriaceae - growth & development
Enterococcus - growth & development
Feces - microbiology
Female
Food Hypersensitivity - drug therapy
Food Hypersensitivity - microbiology
Food Hypersensitivity - pathology
Food Hypersensitivity - veterinary
Lactobacillus - growth & development
Male
Probiotics
Prospective Studies
RNA, Messenger - metabolism
Severity of Illness Index
Treatment Outcome
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Summary:Summary We evaluated whether a probiotic supplementation in dogs with food responsive diarrhoea (FRD) has beneficial effects on intestinal cytokine patterns and on microbiota. Twenty‐one client‐owned dogs with FRD were presented for clinically needed duodeno‐ and colonoscopy and were enrolled in a prospective placebo (PL)‐controlled probiotic trial. Intestinal tissue samples and faeces were collected during endoscopy. Intestinal mRNA abundance of interleukin (IL)‐5, ‐10, ‐12p40 and ‐13, tumour necrosis factor‐α, transforming growth factor‐β1 and interferon (IFN)‐γ were analysed and numbers of Lactobacillus spp., Bifidobacterium spp., Enterococcus spp. and Enterobacteriaceae and supplemented probiotic bacteria were determined in faeces. The Canine Inflammatory Bowel Disease Activity Index, a scoring system comprising general attitude, appetite, faecal consistency, defecation frequency, and vomitus, decreased in all dogs (p 
ISSN:0931-2439
1439-0396
DOI:10.1111/j.1439-0396.2005.00595.x