Hepatitis B virus genotypes and extrahepatic manifestations

This study aimed at correlating the presence of extrahepatic manifestations with hepatitis B virus (HBV) genotypes in patients with chronic HBV infection. This was a national (France), multicenter, retrospective, cross-sectional study. HBV genotypes were determined in 190 patients HBsAg-positive for...

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Bibliographic Details
Published in:Journal of hepatology 2005-11, Vol.43 (5), p.764-770
Main Authors: Cacoub, Patrice, Saadoun, David, Bourlière, Marc, Khiri, Hacene, Martineau, Agnes, Benhamou, Yves, Varastet, Marina, Pol, Stanislas, Thibault, Vincent, Rotily, Michel, Halfon, Philippe
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Cross-Sectional Studies
Epidemiology
Extrahepatic manifestations
France
Genotype
Hepatitis B
Hepatitis B virus - genetics
Hepatitis B virus - metabolism
Hepatitis B, Chronic - physiopathology
Human viral diseases
Humans
Infectious diseases
Liver fibrosis
Male
Medical sciences
Middle Aged
Retrospective Studies
Statistics as Topic
Viral diseases
Viral hepatitis
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Summary:This study aimed at correlating the presence of extrahepatic manifestations with hepatitis B virus (HBV) genotypes in patients with chronic HBV infection. This was a national (France), multicenter, retrospective, cross-sectional study. HBV genotypes were determined in 190 patients HBsAg-positive for at least 6 months and documented before any treatment. Patients were aged 42±15 years and mainly male (77%). Alcohol intake was high in 6% of them, ALT elevated in 73%; 27% were cirrhotic. All HBV genotypes were found, mainly A (24%), D (29%), C (11%), and E (10%). Thirty (16%) patients had clinical extrahepatic manifestations, mainly sensory-motor deficiency, sicca syndrome, myalgia, glomerulonephritis, and arthralgia-arthritis. Their presence was not related to any epidemiologic, viral (including genotypes) or hepatic factor, but to a higher platelet count ( P=0.004). Twenty-nine (15%) patients had biological extrahepatic manifestations, mainly anti-smooth muscle, antinuclear, and anti-nucleosome antibodies. Their presence was related only to anti-HBe antibodies positivity ( P=0.007) or elevated platelet count ( P=0.003). Carrying precore mutant HBV increased by 2.8 folds the risk to have at least one extrahepatic biological manifestation. No relationships between HBV genotypes and the presence of extrahepatic manifestations were evidenced in patients with chronic HBV infection.
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2005.05.029