Evaluation of health-related quality of life in gastroesophageal reflux disease patients before and after treatment with pantoprazole

Gastrooesophageal reflux disease (GERD) is highly prevalent in the Western world but its true population prevalence is difficult to estimate without a validated instrument to detect it. The evaluation of health‐related quality of life (HRQoL) is an useful tool in this assessment. The aims of this st...

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Bibliographic Details
Published in:Diseases of the esophagus 2006-08, Vol.19 (4), p.289-293
Main Authors: De Souza Cury, M., Ferrari, A. P., Ciconelli, R., Ferraz, M. B., Moraes-Filho, J. Prado P.
Format: Article
Language:English
Subjects:
2-Pyridinylmethylsulfinylbenzimidazoles - therapeutic use
Adolescent
Adult
Aged
Anti-Ulcer Agents - therapeutic use
Brazil
Endoscopy, Digestive System
Esophagitis - drug therapy
Esophagitis - psychology
Female
gastroesophageal reflux
Gastroesophageal Reflux - drug therapy
Gastroesophageal Reflux - psychology
heartburn
Humans
Male
Middle Aged
pantoprazole
Prospective Studies
Psychometrics - instrumentation
Quality of Life
Reproducibility of Results
Sickness Impact Profile
Surveys and Questionnaires
Translating
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Summary:Gastrooesophageal reflux disease (GERD) is highly prevalent in the Western world but its true population prevalence is difficult to estimate without a validated instrument to detect it. The evaluation of health‐related quality of life (HRQoL) is an useful tool in this assessment. The aims of this study are to translate and validate a GERD specific HRQoL questionnaire and evaluate HRQoL in a Brazilian population before and after GERD treatment. GERD patients with typical symptoms and Los Angeles Classes A to C esophagitis were included in the study. Two HRQoL questionnaires and upper digestive endoscopy were performed before and after 6 weeks treatment with pantoprazole 40 mg/day followed by 80 mg/day for another 8 weeks if healing did not occur. A generic (SF‐36) and one disease‐specific questionnaire (GERD score) were used. The latter was translated and validated for Brazilian Portuguese. From January 2002 to December 2003, 100 patients were enrolled. Of these, 78 patients were evaluated in a per protocol analysis (35 men, mean age: 40 years). The translated questionnaire (Brazilian GERD Score, BGERDS) demonstrated adequate psychometric properties (validity, responsiveness and reliability). SF‐36 and BGERDS domains significantly improved after treatment (P 
ISSN:1120-8694
1442-2050
DOI:10.1111/j.1442-2050.2006.00581.x